FB2024_03 , released June 25, 2024
Allele: Dmel\Gugunspecified
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General Information
Symbol
Dmel\Gugunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0131792
Feature type
allele
Associated gene
Dmel\Gug
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous somatic clones in the wing lead to a number of defects, including notched wing margins and ectopic vein material. Clones of mutant cells in the intervein regions also alter the hair polarity of the surrounding wild-type cells. In the notum, mutant clones cause notal clefts. In the eye, mutant clones cause small and rough eye. Incorrect rotational direction is seen in wild-type ommatidia adjacent to the clone. Furthermore, both ommatidia rotation and organisation within the mutant eye clone becomes disorganised, with some ommatidia missing outer photoreceptor cells, while others contain extra cells or abnormally shaped rhabdomeres. In embryos lacking maternal Gug, about half fail to develop, all those that do develop have missing and misshaped ventral denticle belts, about 2/3 have holes and patches of naked cuticle. Amongst the embryos with at least one complete ventral denticle belt (just over half) a quarter have obviously widened belts. Hyperplasia of neuronal tissue is also seen in these embryos.

        (Zhang et al., 2002)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhanced by
        Statement
        Reference

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by hb7

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by Kr1

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by hry30

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by hb8

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by kni1

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by kni6

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by kni9

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by rho7M43

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by run29

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by run3

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by sna18

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by tslunspecified

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by Kr9

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by twi1

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by dl1

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by dppunspecified

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by ftz-f103649

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by gtX11

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by hry08247

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by hry25

        (Zhang et al., 2002)

        Gugunspecified has lethal | embryonic stage | maternal effect phenotype, non-enhanceable by hry26

        (Zhang et al., 2002)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Gugunspecified is rescued by Gughs.PZ

        (Zhang et al., 2002)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Atrounspecified
        (Zhang et al., 2002)
        Gugunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (1)