FlyBase Allele Report: Dmel\Arf6[KG02753]

General Information

Symbol

Dmel\Arf6^KG02753

Species

D. melanogaster

Name

FlyBase ID

FBal0134418

Feature type

allele

Associated gene

Dmel\Arf6

Associated Insertion(s)

P{SUPor-P}Arf6^KG02753

Carried in Construct

Also Known As

Arf6^KG, KG02753

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}Arf6^KG02753

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:15,322,998..15,322,998 [-]

(Acevedo et al., 2015, Johnson et al., 2011, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive (with Arf6^EP2612)

(Peru Y Colón de Portugal et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant third instar larvae are capable of synaptic homeostasis at the neuromuscular junction, as indicated by an increase in quantal content in the presence of the glutamate receptor antagonist philanthotoxin-433 (10μM).

(Younger et al., 2013)

Arf51F^KG02753/Arf51F^EP2612 flies are sensitive to ethanol-induced sedation compared to wild-type controls.

(Peru Y Colón de Portugal et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Arf51F[+]/Arf6^KG02753 is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Johnson et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The sensitivity to ethanol-induced sedation seen in Arf51F^KG02753/Arf51F^EP2612 flies is not altered if they also carry RhoGAP18B¹.

The sensitivity to ethanol-induced sedation seen in Arf51F^KG02753/Arf51F^EP2612 flies is not altered if they express Rac1^CA.Scer\UAS under the control of Scer\GAL4^{RhoGAP18B-NP1514} specifically in the adult (using the heat sensitive Scer\GAL80^ts.αTub84B allele to limit expression).

(Peru Y Colón de Portugal et al., 2012)

The ommatidial patterning errors resulting from the expression of cindr^{dsRNA.PC.PD.Scer\UAS} via Scer\GAL4^GMR.PF are strongly enhanced in Arf51F^KG02753 heterozygotes.

(Johnson et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Arf6^EP2612/Arf6^KG02753 is rescued by Arf6^UAS.cCa/Scer\GAL4^elav.PLu

(Peru Y Colón de Portugal et al., 2012)

Arf6^EP2612/Arf6^KG02753 is rescued by Scer\GAL4^NP1514/Arf6^UAS.cCa

(Peru Y Colón de Portugal et al., 2012)

Comments

Expression of Arf51F^Scer\UAS.cCa under the control of Scer\GAL4^elav.PLu rescues the sensitivity of Arf51F^KG02753/Arf51F^EP2612 flies to ethanol-induced sedation.

Expression of Arf51F^Scer\UAS.cCa under the control of Scer\GAL4^{RhoGAP18B-NP1514} throughout development but not in the adult (using the heat sensitive Scer\GAL80^ts.αTub84B allele to limit expression) does not rescue the sensitivity of Arf51F^KG02753/Arf51F^EP2612 flies to ethanol-induced sedation.

Expression of Arf51F^Scer\UAS.cCa under the control of Scer\GAL4^{RhoGAP18B-NP1514} specifically in the adult (using the heat sensitive Scer\GAL80^ts.αTub84B allele to limit expression) does rescue the sensitivity of Arf51F^KG02753/Arf51F^EP2612 flies to ethanol-induced sedation.

(Peru Y Colón de Portugal et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

13763

y¹ w^67c23; P{SUPor-P}Arf6^KG02753

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Arf51F^KG02753

(Huang et al., 2009)

Arf6^KG02753

Arf6^KG

(Acevedo et al., 2015, Peru Y Colón de Portugal et al., 2012)

KG02753

(Peru Y Colón de Portugal et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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