FlyBase Allele Report: Dmel\pygo[130]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\pygo¹³⁰

General Information

Symbol

Dmel\pygo¹³⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0135635

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

pygo^S130

Key Links

Genomic Maps

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kramps et al., 2002)

Progenitor genotype

Cytology

Description

Contains a 14bp deletion starting at amino acid position 751.

(Kramps et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

3R:31,577,367..31,577,380 [-]

Comment:

Approximate location of 14 bp deletion that starts in codon G751 (precise boundaries not reported).

(Kramps et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | germline clone | recessive

(Kramps et al., 2002)

lethal | pupal stage | recessive

(Kramps et al., 2002)

segment polarity phenotype | germline clone | recessive

(Kramps et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous mutant animals derived from homozygous pygo¹³⁰ germ-line clones, dies with a severe segment polarity phenotype. Homozygous mutant animals lacking only the zygotic contribution survive until early pupal stages and have abnormally small imaginal discs.

(Kramps et al., 2002)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

pygo¹³⁰ has lethal | recessive | pupal stage phenotype, suppressible by lgs::pygo^{ΔPHD.HD2.αTub84B}

(Kramps et al., 2002)

pygo¹³⁰ has lethal | recessive | pupal stage phenotype, suppressible by Hsap\PYGO1^αTub84B.PK

(Kramps et al., 2002)

pygo¹³⁰ has lethal | recessive | pupal stage phenotype, suppressible by Hsap\PYGO2^αTub84B.PK

(Kramps et al., 2002)

NOT suppressed by

Statement

Reference

pygo¹³⁰ has lethal | segment polarity expression pattern | recessive | germline clone phenotype, non-suppressible by Apc2^unspecified

(Kramps et al., 2002)

Suppressor of

Statement

Reference

pygo¹³⁰ is a suppressor of visible phenotype of wg^hs.2sev

(Kramps et al., 2002)

Other

Statement

Reference

pb⁵, pygo¹³⁰ has visible | somatic clone phenotype

(Joulia et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

pygo¹³⁰ is a suppressor of eye phenotype of wg^hs.2sev

(Kramps et al., 2002)

pygo¹³⁰ is a suppressor of ommatidium phenotype of wg^hs.2sev

(Kramps et al., 2002)

Other

Statement

Reference

pb⁵, pygo¹³⁰ has leg | ectopic | somatic clone phenotype

(Joulia et al., 2006)

pb⁵, pygo¹³⁰ has labellum | somatic clone phenotype

(Joulia et al., 2006)

pb⁵, pygo¹³⁰ has bract | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

pygo¹³⁰ pb⁵ clones in the labium develop as diminished stubs with residual leg identity (as shown by the presence of bracted bristles).

put^p1 pb⁵ pygo¹³⁰ clones in the labium give rise to leg structures resembling that seen in pb⁵ pygo¹³⁰ clones.

(Joulia et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

pygo^S123/pygo¹³⁰ is rescued by pygo^Tag:HA

(Kessler et al., 2009)

pygo^S123/pygo¹³⁰ is rescued by pygo^Y748A.Tag:HA

(Kessler et al., 2009)

pygo^S123/pygo¹³⁰ is rescued by pygo^A763E.Tag:HA

(Kessler et al., 2009)

pygo^S123/pygo¹³⁰ is rescued by pygo^{Y748A.A763E.Tag:HA}

(Kessler et al., 2009)

pygo^S123/pygo¹³⁰ is rescued by pygo^{Y748A.F773E.Tag:HA}

(Kessler et al., 2009)

pygo¹³⁰ is rescued by pygo^Tag:HA

(Kessler et al., 2009)

pygo¹³⁰ is rescued by pygo^Y748A.Tag:HA

(Kessler et al., 2009)

pygo¹³⁰ is rescued by pygo^A763E.Tag:HA

(Kessler et al., 2009)

pygo¹³⁰ is rescued by pygo^{Y748A.A763E.Tag:HA}

(Kessler et al., 2009)

pygo¹³⁰ is rescued by pygo^{Y748A.F773E.Tag:HA}

(Kessler et al., 2009)

pygo^S123/pygo¹³⁰ is rescued by pygo^+tHa

(Staedeli and Basler, 2005)

pygo¹³⁰ is rescued by pygo^αTub84B.PK

(Kramps et al., 2002)

Not rescued by

pygo^S123/pygo¹³⁰ is not rescued by pygo^V757E.Tag:HA

(Kessler et al., 2009)

pygo^S123/pygo¹³⁰ is not rescued by pygo^L789A.Tag:HA

(Kessler et al., 2009)

pygo¹³⁰ is not rescued by pygo^V757E.Tag:HA

(Kessler et al., 2009)

pygo¹³⁰ is not rescued by pygo^L789A.Tag:HA

(Kessler et al., 2009)

pygo^S123/pygo¹³⁰ is not rescued by pygo^F78A

(Staedeli and Basler, 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Sup¹³⁰

(Kramps et al., 2002)

pygo¹³⁰

(Joulia et al., 2006)

pygo^EB130

(Kessler et al., 2009)

pygo^S130

(Hoffmans et al., 2005, Staedeli and Basler, 2005)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections