FlyBase Allele Report: Dmel\Tl[EP1051]

General Information

Symbol

Dmel\Tl^EP1051

Species

D. melanogaster

Name

FlyBase ID

FBal0136097

Feature type

allele

Associated gene

Dmel\Tl

Associated Insertion(s)

P{EP}Tl^EP1051

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{EP}Tl^EP1051

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:26,798,981..26,798,981 [+]

(Inaki et al., 2010, Cao et al., 2008, Pena-Rangel et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Cao et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^tey-5053A

(Inaki et al., 2010)

Phenotype Manifest In

abdominal segment motor neuron, with Scer\GAL4^tey-5053A

(Inaki et al., 2010)

Detailed Description

Statement

Reference

The nerve terminals synapsed to muscle M12 are greatly reduced in size compared to controls in embryos expressing Tl^EP1051 under the control of Scer\GAL4^tey-5053A.

(Inaki et al., 2010)

Expression using Scer\GAL4^ey.PU does not induce a rough eye phenotype.

(Cao et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^pnr-MD237/Tl^EP1051 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Other

Statement

Reference

Hsap\MAPT^UAS.cWa, Scer\GAL4^ey.PU, Tl^EP1051 has lethal phenotype

(Cao et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

Tl^EP1051, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Tl^EP1051/Scer\GAL4^ey.PU is an enhancer of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

Scer\GAL4^pnr-MD237/Tl^EP1051 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Other

Statement

Reference

Scer\GAL4^pnr-MD237, Tl^EP1051, pnr^MD237 has scutellar bristle phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, Tl^EP1051, pnr^MD237/pnr[+] has scutellar bristle phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing EP1051^EP1051 under the control of Scer\GAL4^pnr-MD237 have deformed scutellar macrochaetae.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EP1051^EP1051

Tl^EP1051

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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