FB2024_03 , released June 25, 2024
Allele: Dmel\mei-P22103
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General Information
Symbol
Dmel\mei-P22103
Species
D. melanogaster
Name
FlyBase ID
FBal0141043
Feature type
allele
Associated gene
Dmel\mei-P22
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Liu et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: R287term.

(Liu et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:7,245,285..7,245,285 [+]
Nucleotide change:

C7245285T

Amino acid change:

R300term | mei-P22-PA

Reported amino acid change:

R287term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Position of mutation on reference sequence inferred by FlyBase curator based on author statement: In the published genome sequence, there is an insertion encoding 13 amino acids (EDSSCAT RRRSLS; MYERS et al. 2000 )

(Liu et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mei-P22103 females show frequent meiotic chromosome segregation errors, as assessed by X-chromosome non-disjunction.

      (Lake et al., 2019)

      Homozygous females show a low frequency (23.8%) of region 3 cysts with two pro-oocytes (as assayed by c(3)G staining).

      (Joyce and McKim, 2009)

      Homozygous females show 37.4% non-disjunction of the X chromosome. Crossing over on the third chromosome (th-ca interval) is reduced to 0.3% of wild type. Exposure of homozygous females to 4000rad of X-irradiation induces crossing over as much as 120-fold compared to unirradiated homozygous females and also decreases X chromosome nondisjunction.

      (Liu et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      mei-P22103 is a non-suppressor of presumptive oocyte phenotype of spn-A1

      (Joyce and McKim, 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The high frequency of region 3 cysts containing two pro-oocytes that is seen in spn-A1 homozygous females is not suppressed by mei-P22103.

      (Joyce and McKim, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mei-P22103 is rescued by Scer\GAL4VP16.nanos.UTR/mei-P22UASp.Tag:HA

      (Lake et al., 2011)

      mei-P22103 is rescued by mei-P22Hsp83.Tag:HA

      (Liu et al., 2002)
      Comments

      Expression of mei-P22Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 fully rescues the meiotic nondisjunction seen in mei-P22103 mutants.

      (Lake et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (9)