FlyBase Allele Report: Dmel\drm[UAS.cGa]

General Information

Symbol

Dmel\drm^UAS.cGa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Green

FlyBase ID

FBal0141171

Feature type

allele

Associated gene

Dmel\drm

Associated Insertion(s)

Carried in Construct

P{UAS-drm.G}

Also Known As

UAS-Drm

Key Links

Transgenic product class

wild_type

(Green et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Green et al., 2002)

Mutagen

in vitro construct

(Green et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-drm.G}

Cytology

Description

UAS regulatory sequences drive expression of full length drm.

(Green et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

drm

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^byn-Gal4

(Green et al., 2002)

lethal, with Scer\GAL4^ptc-559.1

(Hao et al., 2003)

visible, with Scer\GAL4^dpp.PU

(Del Signore et al., 2012)

visible | somatic clone, with Scer\GAL4^Act5C.PI

(Hao et al., 2003)

Phenotype Manifest In

disc epithelium proper & dorsal mesothoracic disc | somatic clone, with Scer\GAL4^Act5C.PU

(Nusinow et al., 2008)

embryonic dorsal epidermis, with Scer\GAL4^ptc-559.1

(Hatini et al., 2005)

embryonic hindgut, with Scer\GAL4^byn-Gal4

(Green et al., 2002)

embryonic small intestine, with Scer\GAL4^byn-Gal4

(Johansen et al., 2003)

eye disc | somatic clone, with Scer\GAL4^Act5C.PP

(Bras-Pereira et al., 2006)

leg & adult cuticle | somatic clone, with Scer\GAL4^Act5C.PI

(Hao et al., 2003)

scutellum, with Scer\GAL4^dpp.PU

(Del Signore et al., 2012)

wing hinge primordium | somatic clone, with Scer\GAL4^Act5C.PU

(Nusinow et al., 2008)

Detailed Description

Statement

Reference

Expression of drm^Scer\UAS.cGa under the control of Scer\GAL4^dpp.PU induces ectopic anterior notum and inhibits scutellum formation.

(Del Signore et al., 2012)

Clones in the wing disc that are generated at the first larval instar and are expressing drm^Scer\UAS.cGa under the control of Scer\GAL4^Act5C survive in the peripodial epithelium but not in the disc proper.

Clones in the disc proper and the posterior lateral margin of the hinge of the wing disc that are generated at the mid- to late third larval instar and are expressing drm^Scer\UAS.cGa under the control of Scer\GAL4^Act5C clones minimise contact with their wild-type neighbours are form round vesicles that extrude basally.

(Nusinow et al., 2008)

Expression of drm^Scer\UAS.cGa under the control of Scer\GAL4^Act5C.PP in clones in the eye disc induces an ectopic furrow and associated ectopic retinogenesis.

(Bras-Pereira et al., 2006)

The 4^o fate of the dorsal epidermis is replaced with 1^o-3^o fates in embryos expressing drm^Scer\UAS.cGa under the control of Scer\GAL4^ptc-559.1.

(Hatini et al., 2005)

Expression of drm^Scer\UAS.cGa in clones in the leg under the control of Scer\GAL4^Act5C.PI results in an indentation in the cuticle, which may occur anywhere along the proximodistal axis of the leg. These clones never induce leg tissue outgrowths.

(Hao et al., 2003)

drm^Scer\UAS.cGa; Scer\GAL4^byn-Gal4 embryos have an expanded small intestine.

(Johansen et al., 2003)

Embryos expressing drm^Scer\UAS.cGa under the control of Scer\GAL4^byn-Gal4 have a short, distended hindgut, which consists of a uniform layer of cuboidal cells (similar to the wild-type small intestine). The boundary cell rows are absent.

(Green et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^Act5C.PP, drm^UAS.cGa has eye disc | somatic clone phenotype, suppressible by bowl¹

(Bras-Pereira et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of drm^Scer\UAS.cGa under the control of Scer\GAL4^Act5C.PP in clones in the eye disc in a bowl¹ background does not result in ectopic retinogenesis.

(Bras-Pereira et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

7072

y¹ w¹¹¹⁸; P{UAS-drm.G}6.1

7073

y¹ w¹¹¹⁸; P{UAS-drm.G}2.1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

drm^Scer\UAS.cGa

drm^UAS.cGa

drmScer\UAS.cGA

(Brás-Pereira and Casares, 2008)

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Green

(Green et al., 2002)

Secondary FlyBase IDs

References (8)

Report Sections

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