FB2024_03 , released June 25, 2024
Allele: Dmel\Mybel1
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General Information
Symbol
Dmel\Mybel1
Species
D. melanogaster
Name
FlyBase ID
FBal0141648
Feature type
allele
Associated gene
Dmel\Myb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

heat sensitive loss of function allele

Mutagen
Nature of the Allele
Allele class

heat sensitive loss of function allele

(Okada et al., 2002)
Mutagen
ethyl methanesulfonate
(Okada et al., 2002)
Progenitor genotype
Cytology
Description

Nucleotide substitution stated in terms of numbering on Accession record X05939.

(Okada et al., 2002)

Nucleotide substitution: C1521T.

(Okada et al., 2002)

Amino acid replacement: Q306term.

(Okada et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:15,856,189..15,856,189 [-]
Nucleotide change:

C15856189T

Reported nucleotide change:

C1521T

Amino acid change:

Q306term | Myb-PA; Q306term | Myb-PB; Q306term | Myb-PD; Q306term | Myb-PE

Reported amino acid change:

Q306term

(Okada et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Less than 50% of hemizygotes survive to the third larval instar.

      (Nomura et al., 2004)

      At 25oC approximately 60% of hemizygotes are embryonic lethal and the rest are lethal at third larval instar or early pupal stage. At 30oC all lethality acts in they embryonic or first larval instar stage.

      (Okada et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Mybel1 has lethal | recessive | larval stage phenotype, non-suppressible by bon21B/bon[+]

      (Nomura et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lethality of Mybel1 hemizygotes is not affected if the flies also carry one copy of bon21B.

      (Nomura et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Mybel1
      dMybel1
      (Okada et al., 2002)
      dmyb1
      (Nomura et al., 2004)
      el1
      (Nomura et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)