FlyBase Allele Report: Dmel\bon[21B]

General Information

Symbol

Dmel\bon^21B

Species

D. melanogaster

Name

FlyBase ID

FBal0125120

Feature type

allele

Associated gene

Dmel\bon

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

bon^S024108

(Beckstead et al., 2001)

Cytology

Description

Imprecise excision of the P{lacW} element removing all but 12bp of exon 1 and the first 324bp of intron 1.

(Beckstead et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cRa

(Rousseaux et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

cell lethal | recessive | somatic clone

(Beckstead et al., 2001)

enhancer of variegation | dominant, with In(1)w^m4h

(Beckstead et al., 2005)

enhancer of variegation | dominant, with P{SUPor-P}25-4-3

(Beckstead et al., 2005)

increased cell death | somatic clone

(Allton et al., 2009)

lethal (with Df(3R)BSC141)

(Miller et al., 2020)

lethal (with Df(3R)BSC488)

(Miller et al., 2020)

lethal | female | first instar larval stage | recessive

(Beckstead et al., 2005)

lethal | first instar larval stage | male | recessive

(Beckstead et al., 2005)

lethal | male (with bon^S043420)

(Beckstead et al., 2005)

lethal | recessive

(Beckstead et al., 2001)

partially lethal | female (with bon^S043420)

(Beckstead et al., 2005)

suppressor of variegation | dominant, with Dp(1;f)γ878

(Beckstead et al., 2005)

suppressor of variegation | dominant, with P{SUPor-P}25-4-3

(Beckstead et al., 2005)

Phenotype Manifest In

adult head & cuticle | somatic clone

(Beckstead et al., 2001)

embryonic/larval salivary gland (with bon^S048706)

(Beckstead et al., 2001)

embryonic/larval tracheal system (with Df(3R)H-B79)

(Beckstead et al., 2001)

eye | P-stage (with bon^S048706)

(Beckstead et al., 2001)

head | P-stage (with bon^S048706)

(Beckstead et al., 2001)

photoreceptor neuron | somatic clone

(Beckstead et al., 2001)

wing | P-stage (with bon^S048706)

(Beckstead et al., 2001)

Detailed Description

Statement

Reference

Clones of bon^21B in wing imaginal discs are small and highly apoptotic.

(Allton et al., 2009)

Homozygous males and females die as first instar larvae. bon^21B/+ enhances the variegation of the w gene in the P{SUPor-P}25-4-3 insertion, but suppresses the variegation of the y gene in the same P{SUPor-P}25-4-3 insertion. bon^21B/+ enhances the variegation of the w gene in the In(1)w^m4h chromosome. bon^21B/+ suppresses the variegation of the y gene in the Dp(1;f)γ878 chromosome.

(Beckstead et al., 2005)

bon^21B/Df(3R)H-B79 embryos fully develop, however many fail to hatch from the egg case. Both embryos and larvae have disrupted fluid-filled trachea. Most bon^S048706/bon^21B pupae have an almost complete lack of pigmentation. They initiate but fail to complete development of the legs, wings, head, eyes and cuticle. Salivary glands are still present 4 days post-pupariation (they normally undergo apoptosis at 12 hours post-pupariation) and are similar in size to third instar salivary glands. Loss of bon function in the eye results in loss of all mutant photoreceptors and much of the head cuticle is missing.

(Beckstead et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

bon^21B has increased cell death | somatic clone phenotype, suppressible by p53^RNAi.UAS/Scer\GAL4^unspecified

(Allton et al., 2009)

Suppressor of

Statement

Reference

bon^21B/bon[+] is a suppressor | partially of lethal phenotype of ari-1³⁷⁴⁷

(Gradilla et al., 2011)

bon^21B/bon[+] is a suppressor of lethal | recessive | larval stage phenotype of Myb^el2507

(Nomura et al., 2004)

NOT Suppressor of

Statement

Reference

bon^21B/bon[+] is a non-suppressor of lethal | recessive | larval stage phenotype of Myb^el1

(Nomura et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

bon^21B/bon[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, fru^NP0021

(Goto et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

A bon^21B background strongly suppresses the rough eye phenotype related to fru isoform B, found upon expression of fru^NP0021 under the control of Scer\GAL4^GMR.PF.

(Goto et al., 2011)

Expression of p53^{dsRNA.Scer\UAS} suppresses apoptosis in bon^21B clones and leads to a significant increase in bon^21B clone size.

(Allton et al., 2009)

80.8% of Myb^el2507/Y ; bon^21B/+ animals survive to the third larval instar. The lethality of Myb^el1 hemizygotes is not affected if the flies also carry one copy of bon^21B.

(Nomura et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

bon^S024108

(Beckstead et al., 2001)

bon^S024912

(Beckstead et al., 2001)

bon^S048706

(Beckstead et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

43660

P{hsFLP}22, y¹ w^*; P{neoFRT}82B bon^21B/TM3, Sb¹

Notes on Origin

Discoverer

Comments

Allelic series: Df(3R)H-B79 > bon^21B > bon^S048706 > bon^S024108 = bon^S024912.

(Beckstead et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Trim28^LOF-2

(Rousseaux et al., 2016)

bon^21B

(Zhao et al., 2023, Rousseaux et al., 2016, Ito et al., 2012, Goto et al., 2011, Gradilla et al., 2011, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15)

Name Synonyms

bonus21B

(Allton et al., 2009)

Secondary FlyBase IDs

References (13)

Report Sections

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