FlyBase Allele Report: Dmel\Myb[ΔC.GMR]

General Information

Symbol

Dmel\Myb^ΔC.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0141656

Feature type

allele

Associated gene

Dmel\Myb

Associated Insertion(s)

Carried in Construct

P{GMR-Myb.ΔC}

Key Links

Transgenic product class

inframe_deletion

(Okada et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Okada et al., 2002)

Mutagen

in vitro construct

(Okada et al., 2002)

Progenitor genotype

Myb^GMR.PO

(Okada et al., 2002)

Carried in construct

P{GMR-Myb.ΔC}

Cytology

Description

Myb protein lacks the 241 amino acids from the C-terminus.

(Okada et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Myb

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle

(Okada et al., 2002)

increased cell death

(Okada et al., 2002)

increased cell death | larval stage

(Okada et al., 2002)

visible | dominant

(Okada et al., 2002)

Phenotype Manifest In

eye

(Okada et al., 2002)

eye disc

(Okada et al., 2002)

eye disc posterior to the morphogenetic furrow | larval stage

(Okada et al., 2002)

eye photoreceptor cell

(Okada et al., 2002)

ommatidium

(Okada et al., 2002)

rhabdomere

(Okada et al., 2002)

Detailed Description

Statement

Reference

Rough eye phenotype. This phenotype is correlated with prolonged M phase in the eye disc. The population of M-phase cells in the region posterior to the morphogenetic furrow of Myb^ΔC.GMR discs is 58% larger than the corresponding region of wild type discs. There is no difference in the region anterior to the morphogenetic furrow. BrdU labeling shows no extra cell cycles posterior to the MF. In cross sections ommatidia contain abnormal numbers of photoreceptor cells. Ommatidia are mis-shapen. Rhabdomeres are immature. Cell death is induced in the eye disc posterior to the morphogenetic furrow, though this does not happen in wild type discs.

(Okada et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Myb^ΔC.GMR has visible | dominant phenotype, suppressible by CycB[+]/CycB¹

(Okada et al., 2002)

Myb^ΔC.GMR has increased cell death phenotype, suppressible by BacA\p35^GMR.PH

(Okada et al., 2002)

Myb^ΔC.GMR has abnormal mitotic cell cycle phenotype, suppressible by CycB[+]/CycB¹

(Okada et al., 2002)

Myb^ΔC.GMR has abnormal mitotic cell cycle phenotype, suppressible by cdc2[+]/Cdk1^E10

(Okada et al., 2002)

Myb^ΔC.GMR has abnormal mitotic cell cycle phenotype, suppressible by nej[+]/nej^unspecified

(Okada et al., 2002)

Myb^ΔC.GMR has abnormal mitotic cell cycle phenotype, suppressible by stg⁴/stg[+]

(Okada et al., 2002)

Myb^ΔC.GMR has visible | dominant phenotype, suppressible by cdc2[+]/Cdk1^E10

(Okada et al., 2002)

Myb^ΔC.GMR has visible | dominant phenotype, suppressible by nej[+]/nej^unspecified

(Okada et al., 2002)

Myb^ΔC.GMR has visible | dominant phenotype, suppressible by stg⁴/stg[+]

(Okada et al., 2002)

NOT suppressed by

Statement

Reference

Myb^ΔC.GMR has visible | dominant phenotype, non-suppressible by BacA\p35^GMR.PH

(Okada et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

Myb^ΔC.GMR has eye phenotype, suppressible by CycB[+]/CycB¹

(Okada et al., 2002)

Myb^ΔC.GMR has eye phenotype, suppressible by cdc2[+]/Cdk1^E10

(Okada et al., 2002)

Myb^ΔC.GMR has eye phenotype, suppressible by nej[+]/nej^unspecified

(Okada et al., 2002)

Myb^ΔC.GMR has eye phenotype, suppressible by stg⁴/stg[+]

(Okada et al., 2002)

Myb^ΔC.GMR has eye disc phenotype, suppressible by BacA\p35^GMR.PH

(Okada et al., 2002)

NOT suppressed by

Statement

Reference

Myb^ΔC.GMR has eye phenotype, non-suppressible by BacA\p35^GMR.PH

(Okada et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Suppression of Myb^ΔC.GMR is complete for the phenotypically moderate P{GMR-Myb.ΔC}F54 line but only partial for the more phenotypically severe P{GMR-Myb.ΔC}F25 line. Suppression is well correlated with number of M-phase cells posterior to the morphogenetic furrow. BacA\p35^GMR.PH suppresses the cell death defect of eye discs posterior to the morphogenetic furrow, but not the rough eye phenotype.

(Okada et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Myb^ΔC.GMR

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close