FlyBase Allele Report: Dmel\Cdk1[E10]

General Information

Symbol

Dmel\Cdk1^E10

Species

D. melanogaster

Name

FlyBase ID

FBal0030732

Feature type

allele

Associated gene

Dmel\Cdk1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Clegg et al., 1993, Stern et al., 1993)

Mutagen

ethyl methanesulfonate

(Clegg et al., 1993, Stern et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid replacement: L176Q. Nucleotide substitution: T?A.

(Clegg et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:10,385,266..10,385,266 [-]

Nucleotide change:

T10385266A

Reported nucleotide change:

T?A

Amino acid change:

L176Q | Cdk1-PA

Reported amino acid change:

L176Q

(Clegg et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage

(Stern et al., 1993)

abnormal size | larval stage

(Stern et al., 1993)

lethal | recessive

(Stern et al., 1993)

lethal - all die before end of pupal stage | recessive

(Clegg et al., 1993)

some die during pupal stage | recessive

(Clegg et al., 1993)

Phenotype Manifest In

embryonic/larval brain

(Clegg et al., 1993)

imaginal disc

(Stern et al., 1993)

imaginal disc | larval stage

(Clegg et al., 1993)

larva

(Stern et al., 1993)

Detailed Description

Statement

Reference

Larvae contain no imaginal discs. Brain development is abnormal.

(Clegg et al., 1993)

Die after pupariation at the larval-pupal interface. Larvae take 1-2 days longer than wild type to reach the wandering stage. Imaginal discs are missing or rudimentary and larval brains are reduced in size. Endoreplication and polytenization of larval cells is normal, as are salivary gland size and intensity of DNA staining of their polytene nuclei.

(Stern et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Cdk1^E10 is a non-enhancer of visible phenotype of Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

Suppressor of

Statement

Reference

cdc2[+]/Cdk1^E10 is a suppressor of increased cell death phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

cdc2[+]/Cdk1^E10 is a suppressor of abnormal mitotic cell cycle phenotype of Myb^ΔC.GMR

(Okada et al., 2002)

cdc2[+]/Cdk1^E10 is a suppressor of visible | dominant phenotype of Myb^ΔC.GMR

(Okada et al., 2002)

NOT Suppressor of

Statement

Reference

Cdk1^E10 is a non-suppressor of visible phenotype of Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

Phenotype Manifest In

Suppressor of

Statement

Reference

cdc2[+]/Cdk1^E10 is a suppressor of eye phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

cdc2[+]/Cdk1^E10 is a suppressor of ommatidium phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

cdc2[+]/Cdk1^E10 is a suppressor of eye phenotype of Myb^ΔC.GMR

(Okada et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cdk1^E10

(Morris et al., 2006)

cdc2^E10

(Tanaka-Matakatsu et al., 2007)

cdc^E10

(Huang and Fischer-Vize, 1996)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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