FB2024_03 , released June 25, 2024
Allele: Dmel\MoeT559D.UAS.Tag:MYC
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General Information
Symbol
Dmel\MoeT559D.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0141660
Feature type
allele
Associated gene
Dmel\Moe
Associated Insertion(s)
Carried in Construct
P{UAS-Moe.myc.T559D}
Also Known As
UAS-Myc-MoeT559D
Key Links
Transgenic product class
missense_variant
(Speck et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Speck et al., 2003)
Mutagen
in vitro construct
(Speck et al., 2003)
Progenitor genotype
MoeUAS.Tag:MYC
(Speck et al., 2003)
Carried in construct
P{UAS-Moe.myc.T559D}
Cytology
Description

Construct: Amino acid replacement: T559D.

(Speck et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Moe
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MoeT559D.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096 results in wings that are curved upwards at the edges.

      (Hughes et al., 2010)

      Animals expressing MoeT559D.Scer\UAS.T:Hsap\MYC in the trachea under the control of Scer\GAL4btl.PS show dorsal trunk extension defects.

      Animals expressing MoeT559D.Scer\UAS.T:Hsap\MYC in the salivary gland under the control of Scer\GAL4fkh.PH develop salivary gland migration defects.

      (Kerman et al., 2008)

      The retinae of flies expressing MoeT559D.Scer\UAS.T:Hsap\MYC (under the control of Scer\GAL4ninaE.PD) are abnormal and reveal the original stage of degeneration after only 2 days illumination.

      (Chorna-Ornan et al., 2005)

      Expression of MoeT559D.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ap-md544 in imaginal disc cells results in a marked upregulation of cortical actin in these cells.

      (Speck et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      MoeT559D.UAS.Tag:MYC/Scer\GAL4Tub.PU is a non-enhancer of eye disc | somatic clone phenotype of MbsT666

      (Lee and Treisman, 2004)
      NOT Suppressor of
      Statement
      Reference

      MoeT559D.UAS.Tag:MYC/Scer\GAL4Tub.PU is a non-suppressor of eye disc | somatic clone phenotype of MbsT666

      (Lee and Treisman, 2004)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Animals co-expressing MoeT559D.Scer\UAS.T:Hsap\MYC and Sip1EP2037 under the control of Scer\GAL4Bx-MS1096 have wings that are dramatically reduced in size and have large blisters and cuticular vesicles.

      (Hughes et al., 2010)

      Expression of the phosphomimetic MoeT559D.Scer\UAS.T:Hsap\MYC transgene, under the control of Scer\GAL4tub, does not affect the MbsT666 mutant photoreceptor localization phenotype.

      (Lee and Treisman, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MoeT559D.Scer\UAS.T:Hsap\MYC
      MoeT559D.UAS.Tag:MYC
      Name Synonyms
      Myc-tagged phosphomimetic Dmoesin
      (Miller, 2003)
      Secondary FlyBase IDs
        References (10)