FB2024_03 , released June 25, 2024
Allele: Dmel\wb4Y18
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General Information
Symbol
Dmel\wb4Y18
Species
D. melanogaster
Name
FlyBase ID
FBal0143114
Feature type
allele
Associated gene
Dmel\wb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Schock and Perrimon, 2003)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Slight irregularities in the apical surface of the salivary gland are seen at stage 12 in mutant embryos. By stage 14/15 the salivary gland tube is buckled.

        (Ismat et al., 2013)

        Germ-line clones exhibit a U shaped embryonic phenotype at low penetrance (about 1%).

        (Schock and Perrimon, 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        wb4Y18 has germ band | germline clone phenotype, enhanceable by scb2

        (Schock and Perrimon, 2003)

        wb4Y18 has embryo | germline clone phenotype, enhanceable by scb2

        (Schock and Perrimon, 2003)
        Enhancer of
        Statement
        Reference

        wb4Y18 is an enhancer of germ band | germline clone phenotype of scb2

        (Schock and Perrimon, 2003)

        wb4Y18 is an enhancer of embryo | germline clone phenotype of scb2

        (Schock and Perrimon, 2003)

        wb[+]/wb4Y18 is an enhancer of wing phenotype of mys8

        (Schock and Perrimon, 2003)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        No significant overgrowth of the neuromuscular junction is seen in FakN30/FakKG00304 third instar larvae which are also heterozygous for wb4Y18.

        (Tsai et al., 2008)

        The addition of wb4Y18/+ to mys8 hemizygotes enhances the wing blister phenotype, so that 28% of wings show a blistering phenotype.

        (Schock and Perrimon, 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        wb4Y18
        (Thuveson et al., 2019, Ismat et al., 2013, Tsai et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)