FB2024_03 , released June 25, 2024
Allele: Dmel\nabSH143
Open Close
General Information
Symbol
Dmel\nabSH143
Species
D. melanogaster
Name
FlyBase ID
FBal0143356
Feature type
allele
Associated gene
Dmel\nab
Associated Insertion(s)
P{lacW}nabSH143
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Félix et al., 2007)
Mutagen
P-element activity
(Oh et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{lacW}nabSH143
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The number of SE2 neurons is normal in nabSH143/nabR52 mutant animals.

      There are no SELK neurons observed in nabSH143/nabR52 mutant animals.

      (Losada-Pérez et al., 2010)

      In nabSH143 embryos, thoracic neuroblast 3-3 (NB3-3T) shows delayed quiescence and prolonged proliferation. (This is also true of many other thoracic neuroblasts in mutant first instar larvae.) Consequently, NB3-3T generates additional EL neurons.

      (Tsuji et al., 2008)

      Most larvae homozygous for nabSH143 die as first instar larvae. Marker analysis indicates that Tv neurons are absent from nabSH143 homozygous first instar larvae.

      (Félix et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      nabSH143/nabNP3537 is rescued by nabUAS.cFa/Scer\GAL4NP3537

      (Félix et al., 2007)
      Comments

      Lethality due to nabSH143/nabNP3537 is rescued by nabScer\UAS.cFa.

      (Félix et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (11)