FB2024_03 , released June 25, 2024
Allele: Dmel\fruB.UAS.cSa
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General Information
Symbol
Dmel\fruB.UAS.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0144302
Feature type
allele
Associated gene
Dmel\fru
Associated Insertion(s)
Carried in Construct
P{UAS-fru.B.S}
Also Known As
UAS-fruB
Key Links
Transgenic product class
dominant_negative_variant
(Song et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Song et al., 2002)
Mutagen
in vitro construct
(Song et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-fru.B.S}
Cytology
Description

UASt regulatory sequences drive expression of fru sequences including a minimal 5' UTR, the BTB domain and common exons and the "B" 3' end (the construct contains a 4.5kb EcoRI-XbaI fragment from fru cDNA no. 25).

(Song et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
fru
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of fruB.Scer\UAS.cSa under the control of Scer\GAL4sca-537.4 results in defects in Fas2-positive and BP102-positive axon tracts in the embryonic central nervous system.

      (Song et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Desat1.PB/fruB.UAS.cSa partially rescues fruKK112763

      (Sun et al., 2023)
      Fails to rescue

      Scer\GAL4elav-C155/fruB.UAS.cSa fails to rescue fruw12/frusat15

      (Song et al., 2002)

      Scer\GAL4sca-537.4/fruB.UAS.cSa fails to rescue fruw12/frusat15

      (Song et al., 2002)
      Comments

      Expression of fruB.Scer\UAS.cSa under the control of Scer\GAL4sca-537.4 does not rescue the axonal tract defects of Fas2-positive and BP102-positive axons in the central nervous system of fruw12/frusat15 embryos, and these embryos have more severe defects in these axons than fruw12/frusat15 embryos which are not expressing fruB.Scer\UAS.cSa. The defects in the dMP2 and vMP2 neurons seen in fruw12/frusat15 embryos are not rescued by expression of fruB.Scer\UAS.cSa under the control of Scer\GAL4sca-537.4. Expression of fruB.Scer\UAS.cSa under the control of Scer\GAL4elav-C155 does not rescue the axonal tract defects of Fas2-positive and BP102-positive axons in the central nervous system of fruw12/frusat15 embryos.

      (Song et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fruB.Scer\UAS.cSa
      fruB.UAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)