FlyBase Allele Report: Dmel\pon::pins[c-pon.UAS]

General Information

Symbol

Dmel\pon::pins^c-pon.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0146896

Feature type

allele

Associated gene

pon::pins

Associated Insertion(s)

Carried in Construct

P{UAS-pon::pins.C-pon}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Cai et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-pon::pins.C-pon}

Cytology

Description

Expression of full length pins fused to the C-terminal portion of pon (codons 495-673) is under the control of UASt sequences.

(Cai et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

pon::pins

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity, with Scer\GAL4^hs.PB

(Cai et al., 2003)

Phenotype Manifest In

neuroblast, with Scer\GAL4^hs.PB

(Cai et al., 2003)

Detailed Description

Statement

Reference

In embryos expressing pon::raps^{c-pon.Scer\UAS}, under the control of Scer\GAL4^hs.PB, 89% of telophase neuroblasts divide normally, 9% undergo symmetric division and 2 % undergo asymmetric division in a reverse orientation relative to wild-type (n=90).

(Cai et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^hs.PB, pon::pins^c-pon.UAS has abnormal cell polarity phenotype, enhanceable by insc²²

(Cai et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^hs.PB, pon::pins^c-pon.UAS has neuroblast phenotype, enhanceable by insc²²

(Cai et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Being mutant for insc²² enhances the penetrance of the symmetric division (9% to 31%) and reverse orientation division (2% to 11%) phenotypes seen in pon::raps^{c-pon.Scer\UAS}; Scer\GAL4^sca-P309 embryos (n=63).

(Cai et al., 2003)

Being mutant for insc²² enhances the penetrance of the symmetric division (9% to 31%), and reverse orientation division (2% to 11%) phenotypes seen in pon::raps^{c-pon.Scer\UAS}; Scer\GAL4^sca-P309 embryos (n=63).

(Cai et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

pon::pins^{c-pon.Scer\UAS}

pon::pins^c-pon.UAS

pon::raps^{c-pon.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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