FB2024_03 , released June 25, 2024
Allele: Dmel\PakUAS.Tag:MYC
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General Information
Symbol
Dmel\PakUAS.Tag:MYC
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Ang
FlyBase ID
FBal0147694
Feature type
allele
Associated gene
Dmel\Pak
Associated Insertion(s)
Carried in Construct
P{UAS-Pak.MYC}
Also Known As
UAS-pak
Key Links
Transgenic product class
cDNA
(Ang et al., 2003)
wild_type
(Ang et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ang et al., 2003)
wild_type
(Ang et al., 2003)
Mutagen
in vitro construct
(Ang et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Pak.MYC}
Cytology
Description

Expression of Tag:MYC tagged Pak cDNA is under the control of UASt sequences.

(Ang et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Pak
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4OK107 results in axon growth and guidance defects in the mushroom body.

      (Ng and Luo, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      PakUAS.Tag:MYC, Scer\GAL4ey-OK107 has abnormal neuroanatomy phenotype, enhanceable by Rho172O/Rho1[+]

      (Ng and Luo, 2004)
      Suppressed by
      Enhancer of
      Statement
      Reference

      PakUAS.Tag:MYC/Scer\GAL4elav.PLu is an enhancer of abnormal neuroanatomy phenotype of robo15, sli1

      (Fan et al., 2003)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      PakUAS.Tag:MYC, Scer\GAL4ey-OK107 has adult mushroom body phenotype, enhanceable by Rho172O/Rho1[+]

      (Ng and Luo, 2004)
      Suppressed by
      Enhancer of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PU at 29[o]C rescues the defects in the dorsal surface of the cuticle seen in Pak14 Pak376A double mutants, but does not effectively suppress the head hole phenotype.

      (Bahri et al., 2010)

      Overexpression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu enhances the longitudinal axon guidance and pCC/MP1 defects seen in transheterozygous sli1, robo5 mutants. An average of 6.1 defects are seen per animal. 55% of segments (calculated as number of defects/segments) show defects. The combination of heterozygous sli2 and pan-neural overexpression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu leads to longitudinal axon ectopic midline crossing defects. An average of 1.2 defects are seen per animal, and an average of 11% of segments have defects.

      (Fan et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      PakUAS.Tag:MYC/Scer\GAL4SG18.1 partially rescues Pak11/Pak6

      (Ang et al., 2003)
      Comments

      Scer\GAL4SG18.1; PakScer\UAS.T:Hsap\MYC (gives expression in olfactory neurons, but not in the brain) rescues the development of most glomeruli in Pak11/Pak6 flies.

      (Ang et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PakScer\UAS.T:Hsap\MYC
      PakUAS.Tag:MYC
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Ang
      (Ang et al., 2003)
      Secondary FlyBase IDs
        References (5)