FlyBase Allele Report: Dmel\LamC[G00158]

General Information

Symbol

Dmel\LamC^G00158

Species

D. melanogaster

Name

FlyBase ID

FBal0147815

Feature type

allele

Associated gene

Dmel\LamC

Associated Insertion(s)

P{PTT-GB}LamC^G00158

Carried in Construct

Also Known As

G00158

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Morin et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{PTT-GB}LamC^G00158

Cytology

Description

The LamC^G00158 insertion maps within the first intron of LamC and also within ttv (LamC is nested within the fifth intron of ttv).

(Schulze et al., 2005)

Insertion maps to AE003814, sense orientation with respect to scaffold, insertion point 61032.

(Morin et al., 2001)

Allele components

Component

Use(s)

Inserted element

Tagged with

green fluorescent protein

Tag:polyHis

epitope tag

purification tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:14,574,569..14,574,569 [+]

(Schulze et al., 2005, Cooley et al., 2003.5, Morin et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with LamC^EP2199)

(Schulze et al., 2005)

lethal (with LamC^EX3)

(Schulze et al., 2005)

lethal (with LamC^EX5)

(Schulze et al., 2005)

lethal (with LamC^EX16)

(Schulze et al., 2005)

lethal (with LamC^EX187)

(Schulze et al., 2005)

lethal (with LamC^EX265)

(Schulze et al., 2005)

lethal (with LamC^EX296)

(Schulze et al., 2005)

lethal (with LamC^EX364)

(Schulze et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

LamC^G00158 is an enhancer of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

LamC^G00158 is an enhancer of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

LamC^EX364

(Schulze et al., 2005)

LamC^EX296

(Schulze et al., 2005)

LamC^EX265

(Schulze et al., 2005)

LamC^EX187

(Schulze et al., 2005)

LamC^EX3

(Schulze et al., 2005)

LamC^EX5

(Schulze et al., 2005)

LamC^EX16

(Schulze et al., 2005)

LamC^EP2199

(Schulze et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

6837

y¹ w¹¹¹⁸; P{PTT-GB}LamC^G00158 ttv^G00158/CyO

35516

w^*; Nup107^E8, P{PTT-GB}LamC^G00158 ttv^G00158/CyO; P{mRFP-Nup107.K}7.1/TM2

Kyoto

110612

y^* w^* P{PTT-GB}LamC^G00158

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

G00158

(Kaltenbach et al., 2007)

LamC^G00158

LamC^G158

lamC^G00158

(Napoletano et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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