FB2024_03 , released June 25, 2024
Allele: Dmel\vls+tMa
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General Information
Symbol
Dmel\vls+tMa
Species
D. melanogaster
Name
FlyBase ID
FBal0148346
Feature type
allele
Associated gene
Dmel\vls
Associated Insertion(s)
Carried in Construct
P{CG10728+tMa}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Masrouha et al., 2003)
wild_type
(Masrouha et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Masrouha et al., 2003)
wild_type
(Masrouha et al., 2003)
Mutagen
in vitro construct
(Masrouha et al., 2003)
Progenitor genotype
Carried in construct
P{CG10728+tMa}
Cytology
Description

Genomic fragment containing the complete vls gene and the 3' part of lok.

(Masrouha et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
vls
Encoded product / tool
vls
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
2L:20,063,120..20,065,792 [-]
Linked to:
EcoRI-HindIII restriction fragment
Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator; the 5' end is approximate.

(Masrouha et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos derived from lok null mothers (Df(2L)pr2b/Df(2L)be408 females carrying P{CG10728+tMa} to rescue vls function and P{barr+tMa} to rescue barr function) have an average of 24.5 pole cells/embryo compared to the wild-type number of 37.3 pole cells/embryo. The progeny of the lok null flies are viable and fertile, they show no increase in the rate of X chromosome nondisjunction compared to controls and females show no defects in meiotic recombination frequency. lok null larvae are not more sensitive to methyl methanesulfonate or hydroxyurea than control larvae. Irradiation does not result in a delay of entry into mitosis in lok null embryos, in contrast to wild-type embryos.

      (Masrouha et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG10728+tMa
      vls+tMa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)