FlyBase Allele Report: Dmel\morgue[EP2367]

General Information

Symbol

Dmel\morgue^EP2367

Species

D. melanogaster

Name

FlyBase ID

FBal0150336

Feature type

allele

Associated gene

Dmel\morgue

Associated Insertion(s)

P{EP}morgue^EP2367

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Hays et al., 2002)

Mutagen

P-element activity

(Hays et al., 2002, Wing et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{EP}morgue^EP2367

Cytology

Description

P{EP} insertion in the 5' untranslated region of morgue.

(Hays et al., 2002)

P{EP} insertion 59bp upstream of the predicted morgue start codon. The P{EP} insert is oriented in the same direction as that of morgue transcription.

(Wing et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:4,444,667..4,444,667 [-]

(Zhou et al., 2013, Walker et al., 2011, Hays et al., 2002, Wing et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death | recessive

(Hays et al., 2002)

viable

(Walker et al., 2011, Hays et al., 2002)

Phenotype Manifest In

pigment cell | increased number (with morgue^EP1184)

(Hays et al., 2002)

Detailed Description

Statement

Reference

Apoptosis in the pigment cell lattice is disrupted in morgue^EP1184/morgue^EP2367 flies, resulting in extra cells in the mature retina.

(Hays et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

morgue^EP2367 is an enhancer of visible phenotype of rst^unspecified

(Hays et al., 2002)

Scer\GAL4^GMR.PF/morgue^EP2367 is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2002)

Other

Statement

Reference

Scer\GAL4^Gp150-52A, grim^UAS.cNa, morgue^EP2367 has increased cell death phenotype

(Wing et al., 2002)

Scer\GAL4^Gp150-52A, morgue^EP2367, rpr^UAS.cZa has increased cell death phenotype

(Wing et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

morgue^EP2367 is an enhancer of ommatidium phenotype of rst^unspecified

(Hays et al., 2002)

Scer\GAL4^GMR.PF/morgue^EP2367 is an enhancer of pigment cell phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2002)

Scer\GAL4^Gp150-52A/morgue^EP2367 is an enhancer of midline glial cell phenotype of Scer\GAL4^Gp150-52A, grim^UAS.cNa

(Wing et al., 2002)

Other

Statement

Reference

Scer\GAL4^Gp150-52A, grim^UAS.cNa, morgue^EP2367 has presumptive embryonic/larval central nervous system phenotype

(Wing et al., 2002)

Scer\GAL4^Gp150-52A, morgue^EP2367, rpr^UAS.cZa has presumptive embryonic/larval central nervous system phenotype

(Wing et al., 2002)

Scer\GAL4^Gp150-52A, morgue^EP2367, rpr^UAS.cZa has midline glial cell phenotype

(Wing et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

morgue^EP2367 enhances the rst^unspecified phenotype, resulting in a more severe disruption of the ommatidial rows.

(Hays et al., 2002)

Co-expression of morgue^EP2367 enhances the eye phenotype caused by expression of grim::rpr^rg.Scer\UAS under the control of Scer\GAL4^GMR.PF; eye pigmentation is reduced. Co-expression of rpr^Scer\UAS.cZa and morgue^EP2367 under the control of Scer\GAL4^Gp150-52A in embryos in the central nervous system midline results in a dramatic loss of midline glia and neurons. Co-expression of morgue^EP2367 and grim^Scer\UAS.cNa under the control of Scer\GAL4^Gp150-52A in embryos in the central nervous system midline results in more severe loss of midline glia than seen in embryos expressing grim^Scer\UAS.cNa alone under the control of Scer\GAL4^Gp150-52A.

(Wing et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

morgue^E290

(Hays et al., 2002)

Rescued by

morgue^EP2367 is rescued by Scer\GAL4^unspecified, morgue^EP2367

(Hays et al., 2002)

Rescues

Scer\GAL4^unspecified, morgue^EP2367 rescues morgue^EP2367

(Hays et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

morgue^EP2367

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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