FB2024_03 , released June 25, 2024
Allele: Dmel\dbrEP9
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General Information
Symbol
Dmel\dbrEP9
Species
D. melanogaster
Name
FlyBase ID
FBal0155409
Feature type
allele
Associated gene
Dmel\dbr
Associated Insertion(s)
P{EP}dbrEP9
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Dai et al., 2003)
Mutagen
P-element activity
(Dai et al., 2003)
Progenitor genotype
dbrEP0456
(Dai et al., 2003)
Associated Insertion(s)
P{EP}dbrEP9
Cytology
Description

Mobilisation of P{EP}dbrEP2220 has produced a new insertion, 489bp upstream of the initiator ATG codon dbr.

(Dai et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Bilen and Bonini, 2007)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dbrEP9 homozygotes and dbrEP9/Df(2L)PM44 animals survive until the larval (90%) and early pupal (10%) stages. In adult wings dbrEP9 mutant clones near the A/P border are associated with pattern malformations: a greater distance between veins 3 and 4 and formation of extra crossvein 1 or extra vein 3 in part. Clones located between vein 1 and 2, are phenotypically wild-type.

      (Dai et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      dbrEP9 is a weak suppressor of the eye degeneration phenotype caused by expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU.

      (Bilen and Bonini, 2007)
      Complementation and Rescue Data
      Partially rescued by

      dbrEP9 is partially rescued by Scer\GAL4hs.PB, dbrEP9

      (Dai et al., 2003)
      Partially rescues

      Scer\GAL4hs.PB, dbrEP9 partially rescues dbrEP9

      (Dai et al., 2003)
      Comments

      Survival of dbrEP9 homozygotes to pupal stages is increased from 10% to 40% at 25oC by Scer\GAL4hs.PB.

      (Dai et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Rescuable by precise excision.

      (Dai et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dbrEP9
      (Kahsai and Cook, 2018, Bilen and Bonini, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)