FlyBase Allele Report: Dmel\bs[Ebr292]

General Information

Symbol

Dmel\bs^Ebr292

Species

D. melanogaster

Name

FlyBase ID

FBal0155545

Feature type

allele

Associated gene

Dmel\bs

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ward et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | recessive

(Ward et al., 2003)

lethal | larval stage | recessive

(Ward et al., 2003)

lethal - all die during embryonic stage (with Df(2R)Px2)

(Ward et al., 2003)

some die during embryonic stage (with Df(2R)Px2)

(Ward et al., 2003)

visible

(Ward et al., 2003)

Phenotype Manifest In

cephalopharyngeal skeleton

(Ward et al., 2003)

cephalopharyngeal skeleton (with Df(2R)Px2)

(Ward et al., 2003)

embryonic/first instar larval cuticle

(Ward et al., 2003)

embryonic/first instar larval cuticle (with Df(2R)Px2)

(Ward et al., 2003)

embryonic/larval tracheal system

(Ward et al., 2003)

wing

(Ward et al., 2003)

Detailed Description

Statement

Reference

Heterozygous adults do not show a malformed leg phenotype. Homozygotes show 18 +/- 3% embryonic lethality. 29% of the dead embryos have dorsal anterior holes and others have abnormal head skeletons. 53 +/- 7% of homozygous larvae fail to form pupae. Terminal branching of the larval trachea is missing. Failure of apposition of the dorsal and ventral wing surfaces is seen in rare pharate adult escapers, resulting in a tube- or balloon-shaped wing.

(Ward et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

bs[+]/bs^Ebr292 is an enhancer of visible phenotype of br¹

(Ward et al., 2003)

Other

Statement

Reference

br⁵, bs[+]/bs^Ebr292 has visible phenotype

(Ward et al., 2003)

br⁵/br[+], bs^Ebr292 has visible | dominant phenotype

(Ward et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

bs[+]/bs^Ebr292 is an enhancer of leg phenotype of br¹

(Ward et al., 2003)

Other

Statement

Reference

br⁵, bs^Ebr292 has leg phenotype

(Ward et al., 2003)

br⁵/br[+], bs^Ebr292 has leg phenotype

(Ward et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

15% of br¹ ; bs^Ebr292/+ flies show a malformed leg phenotype. The predominant leg phenotype in br¹/Y ; bs^Ebr292/+ flies is short, fat femurs and tibias. 10% of br⁵/+ ; bs^Ebr292/+ flies show a malformed leg phenotype. 7% of bs^Ebr292 Rho1^J3.8 double heterozygotes show a malformed leg phenotype in at least one leg. 0% of bs^Ebr292 Rho1^k02107b double heterozygotes show a malformed leg phenotype in at least one leg. 0% of bs^Ebr292 Rho1^E3.10 double heterozygotes show a malformed leg phenotype in at least one leg. 0% of bs^Ebr292 RhoGEF2⁰⁴²⁹¹ double heterozygotes show a malformed leg phenotype in at least one leg. 0% of bs^Ebr292 RhoGEF2^11-3 double heterozygotes show a malformed leg phenotype in at least one leg. 2% of bs^Ebr292 zip^Ebr double heterozygotes show a malformed leg phenotype in at least one leg. 0% of bs^Ebr292 zip¹ double heterozygotes show a malformed leg phenotype in at least one leg. 0% of bs^Ebr292 zip^33-1 double heterozygotes show a malformed leg phenotype in at least one leg.

(Ward et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

bs⁰³²⁶⁷

(Ward et al., 2003)

bs^k07909

(Ward et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a mutation that enhances the br¹ malformed leg phenotype.

(Ward et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

bs^E(br)292

(Ward et al., 2003)

bs^Ebr292

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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