FB2024_03 , released June 25, 2024
Allele: Dmel\SREBPNTdel.UAS
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General Information
Symbol
Dmel\SREBPNTdel.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0156413
Feature type
allele
Associated gene
Dmel\SREBP
Associated Insertion(s)
Carried in Construct
P{UAS-SREBP.NTdel}
Key Links
Transgenic product class
dominant_negative_variant
(Parks, 2004.5.12)
inframe_deletion
(Parks, 2004.5.12)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Parks, 2004.5.12)
inframe_deletion
(Parks, 2004.5.12)
Mutagen
in vitro construct
(Parks, 2004.5.12)
Progenitor genotype
SREBPUAS.Exel
(Parks, 2004.5.12)
Carried in construct
P{UAS-SREBP.NTdel}
Cytology
Description

Deleted for the highly acidic region at the N terminus (amino acids 1-75) and the transmembrane domains.

(Parks, 2004.5.12)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
SREBP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Upon being subjected to pacing-induced stress, hearts expressing HLH106NTdel.Scer\UAS under the control of Scer\GAL4HCH.Hand show lower rates of heart failure compared to control hearts at older ages (4 weeks).

      (Lim et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      SREBPNTdel.UAS/Scer\GAL4GMR.PFa is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive | conditional phenotype of Pectomb593

      (Tsai et al., 2019)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      SREBPNTdel.UAS/Scer\GAL4GMR.PFa is a non-suppressor of axon | somatic clone | adult stage | progressive | conditional phenotype of Pectomb593

      (Tsai et al., 2019)

      SREBPNTdel.UAS/Scer\GAL4GMR.PFa is a non-suppressor of eye photoreceptor cell | somatic clone | adult stage | progressive | conditional phenotype of Pectomb593

      (Tsai et al., 2019)

      SREBPNTdel.UAS/Scer\GAL4GMR.PFa is a non-suppressor of optic cartridge | somatic clone | adult stage | progressive | conditional phenotype of Pectomb593

      (Tsai et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased triglyceride levels seen in the hearts of 1 week old eas2 females are suppressed if they are also expressing HLH106NTdel.Scer\UAS under the control of Scer\GAL4HCH.Hand.

      Expression of HLH106NTdel.Scer\UAS under the control of Scer\GAL4HCH.Hand significantly rescues the increased heartbeat rate, constricted heart phenotype and muscle defects of eas2 flies.

      (Lim et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HLH106NTdel.Scer\UAS
      SREBPNTdel.Scer\UAS
      SREBPNTdel.UAS
      dSREBPDN75T
      (Lim et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)