FB2024_03 , released June 25, 2024
Allele: Dmel\GNBP1e03371
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General Information
Symbol
Dmel\GNBP1e03371
Species
D. melanogaster
Name
FlyBase ID
FBal0156443
Feature type
allele
Associated gene
Dmel\GNBP1
Associated Insertion(s)
PBac{RB}GNBP1e03371
Carried in Construct
Also Known As
GNBP1osi, GNBP1Osiris
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Gobert et al., 2003)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{RB}GNBP1e03371
    Cytology
    Description

    Insertion of PBac{RB} into the second exon of GNBP1 at nucleotide 511, corresponding to amino acid 48 of the preprotein or residue 29 of the predicted mature protein.

    (Gobert et al., 2003)
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{RB}
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        GNBP1e03371 mutant flies show reduced survival rate upon infection with either Staphylococcus aureus or Streptococcus pyogenes compared to wild-type.

        (Iatsenko et al., 2016)

        Mutant flies are susceptible to S. aureus infection compared to wild-type adults.

        (Wang et al., 2008)

        Hemolymph clots from GNBP1e03371 third instar larvae show normal melanization.

        (Bidla et al., 2007)

        Mutant flies show reduced survival compared to wild-type controls after infection with S. aureus.

        (Bischoff et al., 2004)

        Survival rates of mutant flies after injection of Enterococcus faecalis and Streptococcus pyogenes are severely compromised and similar to those of Dif mutants.

        (Gobert et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhanced by
        Statement
        Reference

        GNBP1e03371 has abnormal immune response | adult stage phenotype, non-enhanceable by PGRP-SDsk1

        (Iatsenko et al., 2016)

        GNBP1e03371 has abnormal immune response phenotype, non-enhanceable by PGRP-SAseml

        (Gobert et al., 2003)
        NOT Enhancer of
        Statement
        Reference

        GNBP1e03371 is a non-enhancer of abnormal immune response phenotype of PGRP-SAseml

        (Gobert et al., 2003)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The reduced survival rate of GNBP1e03371 mutant adults upon infection with either Staphylococcus aureus or Streptococcus pyogenes is not worsened further by combination with PGRP-SDsk1.

        (Iatsenko et al., 2016)

        PGRP-SDΔ3 GNBP1e03371 and GNBP1e03371 PGRP-SAseml double mutant flies are extremely susceptible to S. aureus infection compared to wild-type adults.

        (Wang et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Mutants show a significant decrease in the expression of Drs in response to several Gram-positive bacterial strains, but not generally in response to fungi. Dpt expression is normal after a challenge with Gram-negative bacteria. Transfer of hemolymph from wild type to GNBP1e03371 flies restores the inducibility of Drs by Gram-positive challenge. Excision of the PBac{RB} element is accompanied by reversion of the E. faecalis sensitivity mutant phenotype.

        (Gobert et al., 2003)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        References (11)