FB2024_03 , released June 25, 2024
Allele: Dmel\MoeRNAi.818-1326.UAS
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General Information
Symbol
Dmel\MoeRNAi.818-1326.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0176073
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS sequences control expression of an inverted repeat of 818-1236 of Moe (numbering as for GenBank: L38909).

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Moe818-1326.dsRNA.Scer\UAS; Moe327-775.dsRNA.Scer\UAS; Scer\GAL4MD-638 flies have wing phenotypes similar to those due to Moec858 : wings are small (in particular, they are severely shortened along the proximal-distal axis); vesicles form between the dorsal and ventral surfaces of the wing; veination is defective. In the late third instar wing disc, there is ectopic folding of the disc epithelium. This folding sometimes extends back under the disc making transverse sections multi-layered.

Rhabdomeres in the eyes of Moe818-1326.dsRNA.Scer\UAS; Moe327-775.dsRNA.Scer\UAS; Scer\GAL4hs.PB flies heat shocked at approximately 50% pupal development have a disorganised actin cytoskeleton and reduced, irregular microvillar fields. Apical differentiation and organisation of the actin cytoskeleton is severely disrupted in the photoreceptors of Moe818-1326.dsRNA.Scer\UAS; Moe327-775.dsRNA.Scer\UAS; Scer\GAL4GMR.PF animals. Microvillar and stalk membranes in these photoreceptors are distinct but jumbled. Despite these defects, epithelial integrity is maintained, and photoreceptor adherens-junctions appear normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Moe818-1326.dsRNA.Scer\UAS
MoeRNAi.818-1326.UAS
MoedsRNA.818-1326.Scer\UAS
MoedsRNA.818-1326.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)