FlyBase Allele Report: Dmel\twin[ry3]

General Information

Symbol

Dmel\twin^ry3

Species

D. melanogaster

Name

FlyBase ID

FBal0177312

Feature type

allele

Associated gene

Dmel\twin

Associated Insertion(s)

P{}twin^ry3

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{}twin^ry3

Cytology

Description

Insertion in a 15kb intron of twin.

(Morris et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Spradling, 1993)

Phenotype Manifest In

egg chamber

(Morris et al., 2005)

egg chamber (with twin^ry5)

(Morris et al., 2005)

nurse cell ring canal | increased number (with twin^ry5)

(Morris et al., 2005)

oocyte

(Morris et al., 2005)

Detailed Description

Statement

Reference

At room temperature, hemizygous females show a number of egg chamber defects; 37% of egg chambers degrade between stages 3 and 10, 16% have a division defect (the egg chambers contain less than 16 germ cells), 24% fail to specify an oocyte, and 11% have defects in both germ cell number and oocyte specification. The fusome appears normal in size and extends throughout the cysts. Some twin^ry3/twin^ry5 egg chambers contain cells with more than four ring canals, indicating that the cells have divided more than four times.

(Morris et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

twin^ry3 has egg chamber phenotype, suppressible by CycA[+]/CycA^unspecified

(Morris et al., 2005)

twin^ry3 has egg chamber phenotype, suppressible by bam^hs.PO

(Morris et al., 2005)

twin^ry3 has oocyte phenotype, suppressible by bam^hs.PO

(Morris et al., 2005)

NOT suppressed by

Statement

Reference

twin^ry3 has egg chamber phenotype, non-suppressible by CycB[+]/CycB^unspecified

(Morris et al., 2005)

twin^ry3 has egg chamber phenotype, non-suppressible by CycE[+]/CycE^unspecified

(Morris et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of the degrading egg chamber phenotype seen in twin^ry3 hemizygotes is markedly suppressed by CycA^unspecified/+, but is not significantly altered by CycB^unspecified/+ or CycE^unspecified/+. The egg chamber defects seen in twin^ry3 hemizygotes at 25^oC are partly suppressed by expression of bam^hs.PO.

(Morris et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

twin^S1

(Morris et al., 2005)

twin^S3

(Morris et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allelic series: twin^S1 > twin^ry3 ~ twin^ry5 > twin^S3. Precise excision of the P-element reverts the mutant phenotype.

(Morris et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

twin^RY3

(Flora et al., 2018)

twin^ry3

Name Synonyms

Secondary FlyBase IDs

FBal0026861

References (3)

Report Sections

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