FlyBase Allele Report: Dmel\CycB[unspecified]

General Information

Symbol

Dmel\CycB^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0097373

Feature type

allele

Associated gene

Dmel\CycB

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | maternal effect

(Ji et al., 2004)

Phenotype Manifest In

anaphase & condensed nuclear chromosome | maternal effect

(Ji et al., 2004)

aster

(Ji et al., 2002)

embryo | embryonic cycle 6 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 7 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 8 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 9 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 10 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 11 | maternal effect

(Ji et al., 2004)

interphase | maternal effect

(Ji et al., 2004)

mitotic metaphase | maternal effect

(Ji et al., 2004)

mitotic prophase | maternal effect

(Ji et al., 2004)

Detailed Description

Statement

Reference

The velocity of sister chromatid separation in anaphase of mitotic cycles 6-8 increases significantly with increasing maternal CycB gene dosage: CycB^unspecified/+ < wild-type < 2XCycB^+t10. This is reflected in a decrease in anaphase duration. The duration of prophase + metaphase between cycles 6 and 10 increases with increasing maternal CycB gene dosage (genetics as above), but the length of interphase during these cycles decreases with increasing maternal CycB gene dosage (CycB^unspecified/+ > wild-type > 2XCycB^+t10. This latter effect is particularly pronounced in later mitotic cycles (10 and 11).

(Ji et al., 2004)

99% of cycle 5-7 embryos derived from females carrying one copy of CycB⁺ have metaphase spindles with asters, compared to 84% in wild-type controls.

(Ji et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

CycB^unspecified is a non-enhancer of visible phenotype of Wee1^GMR.PP

(Price et al., 2002)

CycB^unspecified is a non-enhancer of visible phenotype of Myt1^GMR.PP

(Price et al., 2002)

CycB^unspecified is a non-enhancer of viable phenotype of Cdk4³

(Meyer et al., 2000)

Suppressor of

Statement

Reference

CycA^unspecified/CycB^unspecified is a suppressor of lethal | maternal effect | embryonic stage phenotype of mei-41^D5/mei-41^D3

(Sibon et al., 1999)

CycB^unspecified is a suppressor of lethal | recessive | maternal effect | embryonic stage phenotype of mei-41^D3

(Sibon et al., 1999)

NOT Suppressor of

Statement

Reference

CycB^unspecified is a non-suppressor of visible phenotype of Myt1^GMR.PP

(Price et al., 2002)

CycB^unspecified is a non-suppressor of visible phenotype of Wee1^GMR.PP

(Price et al., 2002)

CycB^unspecified is a non-suppressor of viable phenotype of Cdk4³

(Meyer et al., 2000)

Other

Statement

Reference

CycA⁵, CycB^unspecified has abnormal mitotic cell cycle phenotype

(Meyer et al., 2002)

CycB^unspecified, mei-41^D5 has lethal | recessive | maternal effect | embryonic stage phenotype

(Sibon et al., 1999)

CycA^unspecified, CycB^unspecified, mei-41^D5/mei-41^D3 has lethal | maternal effect | embryonic stage phenotype

(Sibon et al., 1999)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

CycB^unspecified is a non-enhancer of eye phenotype of Wee1^GMR.PP

(Price et al., 2002)

CycB^unspecified is a non-enhancer of eye phenotype of Myt1^GMR.PP

(Price et al., 2002)

Suppressor of

Statement

Reference

CycB^unspecified is a suppressor of phenotype of rux⁹

(Gonczy et al., 1994)

NOT Suppressor of

Statement

Reference

CycB[+]/CycB^unspecified is a non-suppressor of egg chamber phenotype of twin^ry3

(Morris et al., 2005)

CycB^unspecified is a non-suppressor of eye phenotype of Myt1^GMR.PP

(Price et al., 2002)

CycB^unspecified is a non-suppressor of eye phenotype of Wee1^GMR.PP

(Price et al., 2002)

Other

Statement

Reference

CycA⁵, CycB^unspecified has cell cycle phenotype

(Meyer et al., 2002)

CycA⁵, CycB^unspecified has embryonic dorsal epidermis | lateral phenotype

(Meyer et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of the degrading egg chamber phenotype seen in twin^ry3 hemizygotes is not significantly altered by CycB^unspecified/+.

(Morris et al., 2005)

Cells in the dorsolateral epidermis arrest prematurely in G2 of cycle 15 in CycA⁵/CycB^unspecified embryos. The nuclear density in these embryos is also halved.

(Meyer et al., 2002)

The addition of CycA^unspecified, CycB^unspecified, CycB3^unspecified or cdc2^unspecified have no effect on survival of Cdk4³ homozygotes.

(Meyer et al., 2000)

The lethality of embryos derived from mei-41^D3/mei-41^D5 females is partly rescued if the females are also heterozygous for CycB^unspecified, and greater rescue is seen if the females are also heterozygous for both CycA^unspecified and CycB^unspecified.

(Sibon et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CycB^unspecified

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

Open Close