FlyBase Allele Report: Dmel\CycA[5]

General Information

Symbol

Dmel\CycA⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0002203

Feature type

allele

Associated gene

Dmel\CycA

Associated Insertion(s)

P{hsneo}CycA⁵

Carried in Construct

Also Known As

cycA^neo114, l(3)neo114

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

P-element activity

(Berg and Spradling, 1991, Lehner and O'Farrell, 1989, Cooley et al., 1988)

PM hybrid dysgenesis

(Smith et al., 1993)

Progenitor genotype

Associated Insertion(s)

P{hsneo}CycA⁵

Cytology

Description

P element insertion

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | embryonic stage

(Reber et al., 2006)

abnormal mitotic cell cycle | embryonic stage (with CycA³)

(Reber et al., 2006)

lethal | recessive

(Berg and Spradling, 1991, Lehner and O'Farrell, 1989, Cooley et al., 1988)

Phenotype Manifest In

embryonic/larval tracheal dorsal trunk (with Df(3L)vin3)

(Beitel and Krasnow, 2000)

embryonic/larval tracheal transverse connective (with Df(3L)vin3)

(Beitel and Krasnow, 2000)

embryonic epidermis

(Reber et al., 2006)

embryonic epidermis (with CycA³)

(Reber et al., 2006)

ganglion mother cell GMC1-1a

(Lear et al., 1999)

ganglion mother cell GMC4-2a

(Lear et al., 1999)

larval EL neuron

(Lear et al., 1999)

Detailed Description

Statement

Reference

CycA⁵ and CycA⁵/CycA³ embryos show a failure of epidermal cells to undergo mitosis 16.

(Reber et al., 2006)

Tracheal branches in many CycA⁵/Df(3L)vin3 embryos form with half the normal number of cells, yet have normal diameters and lengths.

(Beitel and Krasnow, 2000)

In mutant embryos, the ganglion mother cells, GMC1-1a and GMC4-2a fail to divide into their normal progeny. The non-dividing GMC1-1a and GMC4-2a cells are larger than normal and sit where its offspring should normally be and appear to adopt aCC and RP2 neuron fates respectively. A loss of approximately 20% of EL neurons is also seen.

(Lear et al., 1999)

Expression of dap^GMR.PdN transgene in CycA⁵ flies has no effect on the eye phenotype.

(de Nooij et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CycA⁵ is an enhancer of visible | recessive phenotype of CycE^JP

(Secombe et al., 1998)

CycA⁵ is an enhancer of decreased occurrence of cell division | larval stage phenotype of CycE^JP

(Secombe et al., 1998)

NOT Enhancer of

Statement

Reference

CycA⁵ is a non-enhancer of abnormal mitotic cell cycle | maternal effect phenotype of png¹⁰⁵⁸/png³³¹⁸

(Lee et al., 2001)

CycA⁵ is a non-enhancer of abnormal mitotic cell cycle | maternal effect phenotype of png¹⁰⁵⁸

(Lee et al., 2001)

CycA⁵ is a non-enhancer of visible phenotype of Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

Suppressor of

Statement

Reference

CycA[+]/CycA⁵ is a suppressor of increased cell death phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycA[+]/CycA⁵ is a suppressor of partially lethal phenotype of dally⁰⁶⁴⁶⁴

(Nakato et al., 2002)

CycA[+]/CycA⁵ is a suppressor of visible phenotype of dally⁰⁶⁴⁶⁴

(Nakato et al., 2002)

CycA⁵ is a suppressor of hyperplasia phenotype of wts^P8

(Tao et al., 1999)

CycA⁵ is a suppressor of hyperplasia phenotype of wts^e26-1

(Tao et al., 1999)

CycA⁵ is a suppressor of increased occurrence of cell division phenotype of wts^e26-1

(Tao et al., 1999)

CycA⁵ is a suppressor of increased body size | pupal stage phenotype of wts^e26-1

(Tao et al., 1999)

CycA⁵ is a suppressor of visible phenotype of rux³

(Thomas et al., 1994)

NOT Suppressor of

Statement

Reference

CycA⁵ is a non-suppressor of visible phenotype of Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

Other

Statement

Reference

CycA⁵, CycB^unspecified has abnormal mitotic cell cycle phenotype

(Meyer et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

CycA⁵ is an enhancer of eye phenotype of CycE^JP

(Secombe et al., 1998)

CycA⁵ is an enhancer of eye disc posterior to the morphogenetic furrow | larval stage phenotype of CycE^JP

(Secombe et al., 1998)

Suppressor of

Statement

Reference

CycA[+]/CycA⁵ is a suppressor of eye phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycA[+]/CycA⁵ is a suppressor of ommatidium phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycA[+]/CycA⁵ is a suppressor of aster | embryonic cycle 5 phenotype of CycB^+t10

(Ji et al., 2002)

CycA[+]/CycA⁵ is a suppressor of aster | embryonic cycle 6 phenotype of CycB^+t10

(Ji et al., 2002)

CycA[+]/CycA⁵ is a suppressor of aster | embryonic cycle 7 phenotype of CycB^+t10

(Ji et al., 2002)

CycA[+]/CycA⁵ is a suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB^+t10

(Ji et al., 2002)

CycA[+]/CycA⁵ is a suppressor of ommatidium phenotype of dally⁰⁶⁴⁶⁴

(Nakato et al., 2002)

CycA[+]/CycA⁵ is a suppressor of wing vein L5 phenotype of dally⁰⁶⁴⁶⁴

(Nakato et al., 2002)

CycA[+]/CycA⁵ is a suppressor of antenna phenotype of dally⁰⁶⁴⁶⁴

(Nakato et al., 2002)

CycA⁵ is a suppressor of eye phenotype of wts^P8

(Tao et al., 1999)

CycA⁵ is a suppressor of pupa phenotype of wts^e26-1

(Tao et al., 1999)

CycA⁵ is a suppressor of phenotype of rux⁹

(Gonczy et al., 1994)

CycA⁵ is a suppressor of phenotype of rux^unspecified

(Gonczy et al., 1994)

CycA⁵ is a suppressor of eye phenotype of rux³

(Thomas et al., 1994)

Other

Statement

Reference

CycA⁵, CycB^unspecified has cell cycle phenotype

(Meyer et al., 2002)

CycA⁵, CycB^unspecified has embryonic dorsal epidermis | lateral phenotype

(Meyer et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Cells in the dorsolateral epidermis arrest prematurely in G2 of cycle 15 in CycA⁵/CycB^unspecified embryos. The nuclear density in these embryos is also halved.

(Meyer et al., 2002)

The lethality seen in dally⁰⁶⁴⁶⁴ homozygotes is reduced if they are also heterozygous for CycA⁵. The penetrance of the eye, antenna and wing defects seen in dally⁰⁶⁴⁶⁴ homozygotes is reduced if they are also heterozygous for CycA⁵.

(Nakato et al., 2002)

Dominantly suppresses the phenotype of wts^P8 or wts^e26-1 homozygotes.

(Tao et al., 1999)

Dominantly enhances the rough eye phenotype of CycE^JP homozygotes. One copy of CycA⁵ has no effect on the reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycE^JP homozygotes. One copy of CycA⁵ enhances the reduction in the number of mitotic cells posterior to the morphogenetic furrow seen in CycE^JP homozygotes.

(Secombe et al., 1998)

Lowering the dose of CycA rescues the rux germline phenotype.

(Gonczy et al., 1994)

Dominantly restores 81% of ommatidia of rux³ to wild type.

(Thomas et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

CycA^j3C8

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

A. Spradling.

Cooley et al.

(Cooley et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CycA⁵

CycA^neo114

(Althoff et al., 2009, Tanaka-Matakatsu et al., 2007, Reber et al., 2006, Meyer et al., 2002, Pritchard and Schubiger, 1996, Edgar et al., 1994, Corbin et al., 1991)

CycA^neo17

CycA^neo

(Zraly et al., 2004)

cycA⁵

(Nakato et al., 2002, Lear et al., 1999)

cycA^ne0114

(Beitel and Krasnow, 2000)

cycA^neo114

(Heriche et al., 2003, Ji et al., 2002, de Nooij et al., 2000, Salzberg et al., 1994, Thomas et al., 1994)

cycA^neo114e

(de Nooij et al., 1996)

cyclin A^neo114

(Tao et al., 1999)

cyclinA^neo114e

(Staehling-Hampton et al., 1999)

l(3)neo114

(Smith et al., 1993, Lehner et al., 1991)

l(3)neo17

(Lee et al., 2001, Beaton, 1999.12.12)

neo114

(Lehner and O'Farrell, 1989)

neo17

(Berg and Spradling, 1991)

Name Synonyms

Secondary FlyBase IDs

FBal0002205

References (35)

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