FB2024_03 , released June 25, 2024
Allele: Dmel\cwof05073
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General Information
Symbol
Dmel\cwof05073
Species
D. melanogaster
Name
FlyBase ID
FBal0177610
Feature type
allele
Associated gene
Dmel\cwo
Associated Insertion(s)
PBac{WH}cwof05073
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}cwof05073
Cytology
Description

Insertion at the end of the first intron.

(Kadener et al., 2007)

Insertion in the first intron of cwo.

(Lim et al., 2007)

Insertion in the first intron.

(Matsumoto et al., 2007)
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cwof05073 adults exhibit a significantly longer circadian period as compared to controls.

      (Rivas et al., 2021)

      51% of mutant flies are arrhythmic for locomotor activity during the first 4 days in free running conditions. The remaining flies have weaker and longer rhythms than controls. After 4 days in constant darkness, 75% of the mutant flies are arrhythmic.

      cwoe04207/cwof05073 flies show long and weak locomotor activity rhythms.

      Homozygous flies have a slow locomotor activity clock under light-dark conditions, and they show a clear delay in morning anticipation. The phase response curve (PRC) of these flies is abnormal when subjected to a light pulse during the last night of light-dark entrainment; the mutant PRC is similar in the early night, but then lags behind the wild-type PRC.

      (Kadener et al., 2007)

      Homozygotes and cwoe04207/cwof05073 flies show dramatic reductions in the strength of behavioural circadian rhythms under constant darkness conditions.

      (Lim et al., 2007)

      cwof05073 flies have a long period phenotype and a substantial proportion of them are arrhythmic.

      (Matsumoto et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      cwof05073 has abnormal circadian rhythm | adult stage phenotype, enhanceable by CipcΔ64

      (Rivas et al., 2021)
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      CipcΔ64, cwof05073 double mutants exhibit decreased rhythmicity strength as compared to controls.

      (Rivas et al., 2021)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      cwoe04207/cwof05073 is rescued by Scer\GAL4tim.PE/cwoUAS.cKa

      (Kadener et al., 2007)
      Partially rescued by

      cwof05073 is partially rescued by cwoTag:MYC,Tag:HA

      (Rivas et al., 2021)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      cwo5073
      (Rivas et al., 2021)
      cwof05073
      (Lim et al., 2007)
      cwof
      (Lim et al., 2007)
      stich1f05073
      Name Synonyms
      Secondary FlyBase IDs
        References (5)