FB2024_03 , released June 25, 2024
Allele: Dmel\par-6RNAi.Sym.UAS
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General Information
Symbol
Dmel\par-6RNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0178503
Feature type
allele
Associated gene
Dmel\par-6
Associated Insertion(s)
Carried in Construct
P{UAS-par-6.RNAi.Sym}
Key Links
Transgenic product class
RNAi_reagent
(Pinheiro and Montell, 2004)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Pinheiro and Montell, 2004)
Mutagen
in vitro construct
(Pinheiro and Montell, 2004)
Progenitor genotype
Carried in construct
P{UAS-par-6.RNAi.Sym}
Cytology
Description

Sense-antisense transcription (driven by two convergent arrays of UAS regulatory sequences) of the 1.5kb coding region of par-6 (from the EST LD08317) results in double stranded RNA (dsRNA) expression.

(Pinheiro and Montell, 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
par-6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Border cell migration is incomplete in 13% of stage 10 egg chambers from (par-6Scer\UAS.Sym par-6Scer\UAS.a.Sym)X2; Scer\GAL4slbo.2.6 flies. This increases to 34% in flies also heterozygous for par-6Δ226 and to 25% if Scer\GAL4upd is present in addition to Scer\GAL4slbo.2.6. The organisation of border cell clusters is abnormal in these flies, a phenotype which is also enhanced by the addtional presence of Scer\GAL4upd : Migrating border cells are abnormally loosely clustered and all show protrusive activity (not just leading and trailing edge cells as in wild-type), sometimes having abnormally long protrusions with one end attached to a distant cell.

      (Pinheiro and Montell, 2004)

      Border cell migration is incomplete in 13% of stage 10 egg chambers from (par-6dsRNA.Sym.Scer\UAS)X2; Scer\GAL4slbo.2.6 flies. This increases to 34% in flies also heterozygous for par-6Δ226 and to 25% if Scer\GAL4upd is present in addition to Scer\GAL4slbo.2.6. The organisation of border cell clusters is abnormal in these flies, a phenotype which is also enhanced by the additional presence of Scer\GAL4upd : Migrating border cells are abnormally loosely clustered and all show protrusive activity (not just leading and trailing edge cells as in wild-type), sometimes having abnormally long protrusions with one end attached to a distant cell.

      (Pinheiro and Montell, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      par-6RNAi.Sym.UAS
      par-6Scer\UAS.Sym
      par-6dsRNA.Sym.Scer\UAS
      par-6dsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0178502
      References (2)