FB2024_03 , released June 25, 2024
Allele: Dmel\ms(3)K81unspecified
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General Information
Symbol
Dmel\ms(3)K81unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0178822
Feature type
allele
Associated gene
Dmel\ms(3)K81
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Telomere fusion or variable nuclear sizes are not observed in ms(3)K81unspecified mutant testes.

        Embryos developing from wild-type eggs fertilised by ms(3)K81unspecified mutant sperm display chromosome configurations that are indicative of end-to-end fusions.

        (Gao et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        NOT suppressed by
        Suppressor of
        Statement
        Reference

        ms(3)K81unspecified is a suppressor of abnormal mitotic cell cycle phenotype of grpfsA4

        (Großhans et al., 2003)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of HipHopms(3)K81.T:Disc\RFP-mCherry in the testis fails to suppress the sterility of ms(3)K81unspecified.

        Expression of HipHopms(3)K81.PG in the testis fails to suppress the sterility of ms(3)K81unspecified.

        HipHop::ms(3)K81aKbHcK.ms(3)K81.T:Avic\GFP suppresses ms(3)K81unspecified sterility, although rather poorly.

        HipHop::ms(3)K81aKbKcH.ms(3)K81.T:Avic\GFP is unable to suppress the sterility of ms(3)K81unspecified mutants.

        HipHop::ms(3)K81aHbHcK.ms(3)K81.T:Avic\GFP suppresses the sterility associated with ms(3)K81unspecified, although rather poorly.

        HipHop::ms(3)K81aHbKcK.ms(3)K81.T:Avic\GFP suppresses the sterility associated with ms(3)K81unspecified.

        (Gao et al., 2011)

        In haploid grpfsA4 embryos, created by fertilization of eggs by ms(3)K81unspecified fathers, chromosomes arrest at cycle 14, as in wild-type embryos. This is in contrast to the premature arrest seen in diploid grpfsA4 embryos.

        (Großhans et al., 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        ms(3)K81unspecified is rescued by ms(3)K81UAS.K81.EGFP

        (Gao et al., 2011)
        Not rescued by

        ms(3)K81unspecified is not rescued by ms(3)K81PTV.UAS.K81.EGFP

        (Gao et al., 2011)
        Comments

        ms(3)K81cGa.T:Avic\GFP rescues the male fertility phenotype in ms(3)K81unspecified mutants.

        ms(3)K81PTV.T:Avic\GFP is unable to rescue the sterility of ms(3)K81unspecified mutants.

        (Gao et al., 2011)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        ms(3)K81unspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (3)