FlyBase Allele Report: Dmel\hpo[UAS.cPa]

General Information

Symbol

Dmel\hpo^UAS.cPa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Pantalacci

FlyBase ID

FBal0179449

Feature type

allele

Associated gene

Dmel\hpo

Associated Insertion(s)

Carried in Construct

P{UAS-hpo.P}

Also Known As

UAS-hpo

Key Links

Transgenic product class

wild_type

(Pantalacci et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Pantalacci et al., 2003)

Mutagen

in vitro construct

(Pantalacci, 2003, Pantalacci et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-hpo.P}

Cytology

Description

UASt sequences drive expression of hpo sequence.

(Pantalacci et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

hpo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | somatic clone, with Scer\GAL4^Act5C.PP

(Pantalacci et al., 2003)

decreased cell number | somatic clone, with Scer\GAL4^Act5C.PP

(Pantalacci et al., 2003)

increased cell death, with Scer\GAL4^GMR.PF

(Silva, 2006, Pantalacci, 2003)

Phenotype Manifest In

eye-antennal disc, with Scer\GAL4^Act5C.PP

(Pantalacci et al., 2003)

eye-antennal disc, with Scer\GAL4^GMR.PF

(Pantalacci, 2003)

wing disc | somatic clone, with Scer\GAL4^unspecified

(Fernández et al., 2011)

Detailed Description

Statement

Reference

Clones in the wing disc expressing hpo^Scer\UAS.cPa under the control of Scer\GAL4^unspecified are very small in size and seem to have slightly reduced levels of apical F-actin.

Expression of hpo^Scer\UAS.cPa under the control of Scer\GAL4^hh-Gal4 from the early third larval instar onwards (the temperature sensitive Scer\GAL80^ts.αTub84B allele is used to restrict expression before this stage) does not disrupt the apical F-actin network in the wing disc.

(Fernández et al., 2011)

Overexpression of hpo^Scer\UAS.cPa in the developing eye, under the control of Scer\GAL4^GMR.PF induces cell death.

(Silva, 2006, Silva et al., 2006)

Expression of hpo^Scer\UAS.cPa, in eye imaginal disc somatic clones results in cell cycle arrest before the second mitotic wave.

(Pantalacci et al., 2003)

Scer\GAL4^GMR.PF-driven hpo^Scer\UAS.cPa expression strongly induces apoptosis in the posterior part of the eye imaginal disc.

(Pantalacci, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, hpo^UAS.cPa has increased cell death phenotype, non-suppressible by sav³

(Pantalacci, 2003)

Suppressor of

Statement

Reference

hpo^UAS.cPa/Scer\GAL4^Bx-MS1096 is a suppressor of neoplasia | larval stage phenotype of Alg3^tid2/Alg3^tid1

(de Vreede et al., 2018)

Other

Statement

Reference

Scer\GAL4^GMR.PF, ft⁸, hpo^UAS.cPa has increased cell death | larval stage phenotype

(Silva et al., 2006)

Scer\GAL4^GMR.PF, ft⁸, hpo^UAS.cPa has increased cell death phenotype

(Silva, 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

hpo^UAS.cPa/Scer\GAL4^Bx-MS1096 is a suppressor | partially of wing disc phenotype of Alg3^tid2/Alg3^tid1

(de Vreede et al., 2018)

Other

Statement

Reference

Scer\GAL4^GMR.PF, ft⁸, hpo^UAS.cPa has eye disc | larval stage phenotype

(Silva et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of hpo^Scer\UAS.cPa in the developing eye, under the control of Scer\GAL4^GMR.PF induces cell death in ft⁸ mutant cells.

(Silva, 2006, Silva et al., 2006)

W^GMR.PG-induced apoptosis is blocked in hpo^{dsRNA.Scer\UAS} mutant clones.

(Pantalacci et al., 2003)

Scer\GAL4^GMR.PF-driven hpo^Scer\UAS.cPa expression-induced apoptosis is largely unimpaired in sav³ mutant clones.

(Pantalacci, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

600509

w^*; P{UAS-hpo.P}3

600508

w^*; P{UAS-hpo.P}2; MKRS/TM6B, Tb⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

hpo^Scer\UAS.cPa

hpo^UAS.cPa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Pantalacci

(Pantalacci et al., 2003)

Secondary FlyBase IDs

References (11)

Report Sections

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