FlyBase Allele Report: Dmel\dap[UAS.cUa]

General Information

Symbol

Dmel\dap^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0180253

Feature type

allele

Associated gene

Dmel\dap

Associated Insertion(s)

Carried in Construct

P{UAS-dap.U}

Also Known As

UAS-dacapo, UAS-dap

Key Links

Transgenic product class

wild_type

(Griffiths and Hidalgo, 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Griffiths and Hidalgo, 2004)

Mutagen

in vitro construct

(Griffiths and Hidalgo, 2004)

Progenitor genotype

Carried in construct

P{UAS-dap.U}

Cytology

Description

UAS regulatory sequences drive expression of dap.

(Griffiths and Hidalgo, 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dap

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Delta^UAS.cDa, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^salm.EPv

(Barrios et al., 2015)

Phenotype Manifest In

wing, with Scer\GAL4^salm.EPv

(Barrios et al., 2015)

Detailed Description

Statement

Reference

Expression of dap^Scer\UAS.cUa under the control of Scer\GAL4^salm.EPv results in a reduction in wing size and cell number and causes wing notches.

(Barrios et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

dap^UAS.cUa/Scer\GAL4^salm.EPv is an enhancer of visible phenotype of Scer\GAL4^salm.EPv, caup^UAS.Tag:HA

(Barrios et al., 2015)

Suppressor of

Statement

Reference

dap^UAS.cUa/Scer\GAL4^elav.PU is a suppressor of increased cell number | embryonic stage phenotype of kuz^e29-4

(Bivik et al., 2016)

dap^UAS.cUa/Scer\GAL4^elav.PU is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of kuz^e29-4

(Bivik et al., 2016)

dap^UAS.cUa, Scer\GAL4^ey.PH is a suppressor of neoplasia phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

dap^UAS.cUa/Scer\GAL4^salm.EPv is an enhancer of wing phenotype of Scer\GAL4^salm.EPv, caup^UAS.Tag:HA

(Barrios et al., 2015)

dap^UAS.cUa/Scer\GAL4^salm.EPv is an enhancer of wing vein phenotype of Scer\GAL4^salm.EPv, caup^UAS.Tag:HA

(Barrios et al., 2015)

Suppressor of

Statement

Reference

dap^UAS.cUa/Scer\GAL4^elav.PU is a suppressor of larval EL neuron | increased number | embryonic stage phenotype of kuz^e29-4

(Bivik et al., 2016)

dap^UAS.cUa/Scer\GAL4^elav.PU is a suppressor of apterous-expressing neuron of the lateral cluster of the thorax | increased number | embryonic stage phenotype of kuz^e29-4

(Bivik et al., 2016)

dap^UAS.cUa, Scer\GAL4^ey.PH is a suppressor of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of dap^Scer\UAS.cUa under the control of Scer\GAL4^elav.PU partially suppresses the increased Ap neuron number phenotype, and fully suppresses the increased EL neuron number phenotype, and suppresses the increased daughter cell proliferation of kuz^e29-4/kuz^e29-4 mutants.

(Bivik et al., 2016)

Expression of dap^Scer\UAS.cUa enhances the wing phenotypes seen when caup^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^salm.EPv.

(Barrios et al., 2015)

Co-expression of dap^Scer\UAS.cUa leads to a significant inhibition of the tumor occurrence and a partial reduction in the metastasis seen in 'eyeful' (Scer\GAL4^ey.PH, Dl^Scer\UAS.cDa, psq^GS88A8, lola^GS88A8) flies.

(Bossuyt et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dap^Scer\UAS.cUa

dap^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

(Griffiths and Hidalgo, 2004)

Secondary FlyBase IDs

References (6)

Report Sections

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