FlyBase Allele Report: Dmel\RpL38[2b1]

General Information

Symbol

Dmel\RpL38^2b1

Species

D. melanogaster

Name

FlyBase ID

FBal0181803

Feature type

allele

Associated gene

Dmel\RpL38

Associated Insertion(s)

Carried in Construct

Also Known As

E-2b¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Coelho et al., 2005, Marygold et al., 2005)

Progenitor genotype

Cytology

Description

Nucleotide substitution: T2G. Amino acid replacement: M1R.

(Marygold et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:4,516,318..4,516,318 [-]

Nucleotide change:

T4516318G

Reported nucleotide change:

T?G

Amino acid change:

M1R | RpL38-PA; M1R | RpL38-PB

Reported amino acid change:

M1R

(Marygold et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | dominant

(Marygold et al., 2005)

increased cell size | dominant

(Marygold et al., 2005)

lethal (with RpL38^NC21)

(Marygold et al., 2005)

lethal | embryonic stage (with RpL38^2b2)

(Coelho et al., 2005)

lethal | larval stage (with RpL38^2b2)

(Coelho et al., 2005)

lethal - all die during embryonic stage (with RpL38^2b2)

(Marygold et al., 2005)

Minute

(Marygold et al., 2007)

Minute (with RpL38^NC21)

(Marygold et al., 2005)

Minute | dominant

(Coelho et al., 2005, Marygold et al., 2005)

some die during embryonic stage (with RpL38^2b2)

(Marygold et al., 2005)

visible (with RpL38^NC21)

(Marygold et al., 2005)

Phenotype Manifest In

chaeta

(Coelho et al., 2005, Marygold et al., 2005)

chaeta (with RpL38^NC21)

(Marygold et al., 2005)

wing (with RpL38^NC21)

(Marygold et al., 2005)

wing hair (with RpL38^NC21)

(Marygold et al., 2005)

wing vein | ectopic (with RpL38^NC21)

(Marygold et al., 2005)

Detailed Description

Statement

Reference

Heterozygotes have a Minute bristle phenotype. RpL38^2b1/RpL38^2b2 animals die either as embryos or soon after hatching.

(Coelho et al., 2005)

Heterozygous adults eclose with a delay of about a day compared to control flies and have a medium Minute bristle phenotype. Wing area is increased in heterozygous adults compared to controls, due to an increase in cell size (without any effect on the total number of cells in the wing). RpL38^2b1/RpL38^NC21 animals show 2% viability and have a strong Minute small-bristle phenotype. These animals also show extra venation on the wing and wing hair polarity is often disorganised.

(Marygold et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

RpL38[+]/RpL38^2b1 is an enhancer of visible phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

RpL38[+]/RpL38^2b1 is an enhancer of visible phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

Suppressor of

Statement

Reference

RpL38[+]/RpL38^2b1 is a suppressor of visible phenotype of CycE^JP

(Lin et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

RpL38[+]/RpL38^2b1 is an enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

RpL38[+]/RpL38^2b1 is an enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

NOT Enhancer of

Statement

Reference

RpL38[+]/RpL38^2b1 is a non-enhancer of wing vein phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

Suppressor of

Statement

Reference

RpL38[+]/RpL38^2b1 is a suppressor of eye phenotype of CycE^JP

(Lin et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype seen in homozygous CycE^JP adults is suppressed by RpL38^2b1.

(Lin et al., 2011)

RpL38^2b1 dominantly enhances the small wing phenotype caused by expression of argos^Scer\UAS.cMa under the control of Scer\GAL4^Bx-MS1096, but does not enhance the argos^Scer\UAS.cMa ; Scer\GAL4^Bx-MS1096 wing vein loss phenotype.

(Coelho et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant modifier of the small wing phenotype caused by expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096.

(Coelho et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E-2b¹

(Coelho et al., 2005, Marygold et al., 2005)

RpL38^2b1

(Lin et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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