FB2024_03 , released June 25, 2024
Allele: Dmel\CYLDf00814
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General Information
Symbol
Dmel\CYLDf00814
Species
D. melanogaster
Name
FlyBase ID
FBal0184449
Feature type
allele
Associated gene
Dmel\CYLD
Associated Insertion(s)
PBac{WH}CYLDf00814
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}CYLDf00814
Cytology
Description

Insertion in the first intron.

(Tsichritzis et al., 2007)
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CYLDf00814 mutants are significantly more likely to die from Serratia marcescens infection than their wild-type counterparts.

      (Bandarra et al., 2015)

      CYLDf00814 mutants exhibit a significant reduction in survival under hypoxic conditions, as compared to controls.

      (Bandarra et al., 2014)

      Homozygotes do not show any obvious external morphological anomalies.

      The majority of homozygous adult females have fat body cells of an abnormal size and morphology, although staining with Nile red indicates that the fat body cells are able to accumulate lipids in adult homozygotes. Adult homozygotes have significantly more but smaller lipid droplets compared to wild-type controls. Total triglyceride content is increased by 79.8% in adult homozygotes compared with controls.

      Homozygous adults show increased survival under starvation conditions compared to controls.

      Homozygous flies show a reduced rate of survival compared to control flies following infection with Gram-positive (Enterococcus faecalis) or Gram-negative (E.coli) bacteria.

      (Tsichritzis et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CYLDf00814
      (Bandarra et al., 2014, Tsichritzis et al., 2007)
      cyldf00814
      (Bandarra et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)