FlyBase Allele Report: Dmel\Kdm2[DG12810]

General Information

Symbol

Dmel\Kdm2^DG12810

Species

D. melanogaster

Name

FlyBase ID

FBal0187731

Feature type

allele

Associated gene

Dmel\Kdm2

Associated Insertion(s)

P{wHy}Kdm2^DG12810

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zheng et al., 2014)

Mutagen

P-element activity

(Gelbart, 2008.3.31)

Progenitor genotype

Associated Insertion(s)

P{wHy}Kdm2^DG12810

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:9,057,301..9,057,301 [-]

(Zheng et al., 2014, Gelbart, 2008.3.31, Myrick et al., 2005.5.16)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Song et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Lagarou et al., 2008)

lethal - all die before end of P-stage

(Zheng et al., 2014)

partially lethal - majority die | recessive

(Li et al., 2010)

some die during third instar larval stage

(Zheng et al., 2014)

viable (with Df(3R)J16)

(Zheng et al., 2014)

viable (with Df(3R)J18)

(Zheng et al., 2014)

viable (with Kdm2^d00170)

(Zheng et al., 2014)

viable (with Kdm2^d02926)

(Zheng et al., 2014)

viable (with Kdm2^d06162)

(Zheng et al., 2014)

viable (with Kdm2^d06730)

(Zheng et al., 2014)

viable (with Kdm2^EP3093)

(Zheng et al., 2014)

viable (with Kdm2^EY01336)

(Zheng et al., 2014)

viable (with Kdm2^F11.1)

(Zheng et al., 2014)

viable (with Kdm2^f02828)

(Zheng et al., 2014)

viable (with Kdm2^J15)

(Zheng et al., 2014)

viable (with Kdm2^KG04325)

(Zheng et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous adults eclose at 62% of the expected frequency, and these adults are phenotypically normal and fertile.

(Li et al., 2010)

Heterozygotes do not display obvious homeotic transformations.

(Lagarou et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Kdm2^DG12810 has partially lethal - majority die phenotype, enhanceable by Kdm5^k06801

(Li et al., 2010)

Enhancer of

Statement

Reference

Kdm2^DG12810/Kdm2^DG12810 is an enhancer of lethal | recessive phenotype of Kdm5^k06801

(Li et al., 2010)

Kdm2[+]/Kdm2^DG12810 is an enhancer of homeotic phenotype of Pc¹

(Lagarou et al., 2008)

Kdm2[+]/Kdm2^DG12810 is an enhancer of homeotic phenotype of Pc³

(Lagarou et al., 2008)

Suppressor of

Statement

Reference

Kdm2[+]/Kdm2^DG12810 is a suppressor of visible | dominant phenotype of Snr1^E1

(Curtis et al., 2011)

Kdm2[+]/Kdm2^DG12810 is a suppressor of homeotic phenotype of ash1¹⁰

(Lagarou et al., 2008)

Kdm2[+]/Kdm2^DG12810 is a suppressor of homeotic phenotype of trx¹

(Lagarou et al., 2008)

Other

Statement

Reference

Kdm2^DG12810, Kdm5^k06801 has lethal | first instar larval stage phenotype

(Li et al., 2010)

Kdm2^DG12810, Kdm5^k06801 has lethal | second instar larval stage phenotype

(Li et al., 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

Kdm2[+]/Kdm2^DG12810 is a suppressor of wing vein | ectopic phenotype of Snr1^E1

(Curtis et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

lid^k06801 Kdm2^DG12810 double homozygotes show enhanced lethality compared to either single mutant, dying during the first and second larval instar stages.

(Li et al., 2010)

The frequency of homeotic transformations is significantly higher in flies transheterozygous for Pc¹ or Pc³ and Kdm2^DG12810, compared to flies heterozygous for Pc¹ or Pc³ alone.

The frequency of homeotic transformations is strikingly reduced in flies transheterozygous for trx¹ or ash1¹⁰ and Kdm2^DG12810, compared to flies heterozygous for trx¹ or ash1¹⁰ alone.

(Lagarou et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG11033^DG12810

JHDM1^DG12810

Kdm2^DG12810

(Song et al., 2018, Zheng et al., 2014)

P(CG11033)^DG12810

(Curtis et al., 2011)

dKDM2^DG18120

(Li et al., 2010)

dkdm2^DG12810

(Lagarou et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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