FB2024_03 , released June 25, 2024
Allele: Dmel\foxounspecified
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General Information
Symbol
Dmel\foxounspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0189949
Feature type
allele
Associated gene
Dmel\foxo
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        foxounspecified mutants are unable to sustain sleep:wake rhythms in the presence of the oxidative stress-producing agent paraquat.

        (Koh et al., 2006)

        foxounspecified larvae show an increased sensitivity against starvation. The median life-span of a foxounspecified larvae is approximately 20-21 hours (similar to a ThorΔ1034-2617 larvae).

        (Tettweiler, 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        foxounspecified has short lived phenotype, suppressible by Scer\GAL4Act5C.PU/ThorUAS.cTa

        (Tettweiler, 2005)
        NOT Enhancer of
        Statement
        Reference

        foxo[+]/foxounspecified is a non-enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        NOT Suppressor of
        Statement
        Reference

        foxounspecified/foxounspecified is a non-suppressor of long lived | RU486 conditional phenotype of Scer\GAL4Switch1.106, aopACT.UAS

        (Alic et al., 2014)

        foxo[+]/foxounspecified is a non-suppressor of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Other
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        foxo[+]/foxounspecified is a non-enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        NOT Suppressor of
        Statement
        Reference

        foxo[+]/foxounspecified is a non-suppressor of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Homozygous foxounspecified does not suppress the increase in lifespan seen when aopACT.Scer\UAS is expressed in the adult gut and fat body under the control of Scer\GAL4Switch1.106.

        (Alic et al., 2014)

        While both single mutants are viable to adulthood, foxounspecified, srlKG08646 double mutants show larval lethality.

        (Tiefenböck et al., 2010)

        foxounspecified suppresses the reduced triglyceride phenotype see in Df(3L)meltΔ1 homozygous embryos.

        (Teleman et al., 2005)

        The foxounspecified lifespan phenotype can be rescued through overexpression of ThorScer\UAS.cTa (under the regulation of Scer\GAL4Act5C) to wild-type levels (median life-span of 27 hours), indicating that Thor may mediate nutritional stress resistance downstream of foxo.

        (Tettweiler, 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        dFOXOnull
        (Tettweiler, 2005)
        foxounspecified
        Name Synonyms
        foxo mutant
        (Teleman et al., 2005)
        Secondary FlyBase IDs
          References (8)