FB2024_03 , released June 25, 2024
Allele: Dmel\ThorT37A.T46A.UAS
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General Information
Symbol
Dmel\ThorT37A.T46A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0190856
Feature type
allele
Associated gene
Dmel\Thor
Associated Insertion(s)
Carried in Construct
P{UAS-Thor.T37A.T46A}
Also Known As
4E-BP(AA), UAS-4E-BP(AA)
Key Links
Transgenic product class
missense_variant
(Teleman et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Teleman et al., 2005)
Mutagen
in vitro construct
(Teleman et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Thor.T37A.T46A}
Cytology
Description

UAS regulatory sequences drive expression of a mutated constitutively active form of Thor (carries the amino acid replacements T37A and T46A).

(Teleman et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Thor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ThorT37A.T46A.Scer\UAS under the control of Scer\GAL4en-e16E results in a reduction in total wing area compared to control flies. A reduction in area of both the wing compartment expressing the ThorT37A.T46A.Scer\UAS transgene and the neighbouring, non-expressing wing compartment is seen.

      An increase in the number of TUNEL-positive cells is seen in the territory of ThorT37A.T46A.Scer\UAS expression in wing discs expressing ThorT37A.T46A.Scer\UAS under the control of Scer\GAL4en-e16E, as well as in adjacent cells that are not expressing ThorT37A.T46A.Scer\UAS.

      (Mesquita et al., 2010)

      Ectopic overexpression of ThorT37A.T46A.Scer\UAS, under the control of Scer\GAL4unspecified in the wing disc does not cause any reduction or growth in final wing size. Flies expressing ThorT37A.T46A.Scer\UAS, under the control of Scer\GAL4unspecified have elevated levels of body fat compared with control flies, even when normalised to total body protein.

      (Teleman et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ThorT37A.T46A.Scer\UAS dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

      Expression of ThorT37A.T46A.Scer\UAS under the control of Scer\GAL4ppk.PG fully strongly suppresses the dendrite pruning defects seen in lin19EX mutant ddaC neuron clones at 16 hours after puparium formation. No difference is seen at the white prepupal stage.

      (Wong et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ThorT37A.T46A.Scer\UAS
      ThorT37A.T46A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)