FB2024_03 , released June 25, 2024
Allele: Dmel\Gcn5C137Y
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General Information
Symbol
Dmel\Gcn5C137Y
Species
D. melanogaster
Name
FlyBase ID
FBal0192086
Feature type
allele
Associated gene
Dmel\Gcn5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Carre et al., 2005)
Mutagen
ethyl methanesulfonate
(Carre et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: C137Y.

(Carre et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:12,523,494..12,523,494 [-]
Nucleotide change:

G12523494A

Amino acid change:

C137Y | Gcn5-PA

Reported amino acid change:

C137Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Carre et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PcafE333st/PcafC137T animals form their puparium normally, but during pupation they fail to elongate their metathoracic legs correctly and to deposit some or all abdominal cuticle. Rare adult escapers have misshapen wings, rough eyes, and crooked and twisted metathoracic legs and die a few hours after eclosion.

      (Carre et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Gcn5C137Y/Gcn5[+] is a suppressor | partially of visible phenotype of Scer\GAL4Ser.PGF, Sin3ARNAi.UAS.WIZ

      (Swaminathan and Pile, 2010)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Gcn5C137Y/Gcn5[+] is a suppressor | partially of wing blade phenotype of Scer\GAL4Ser.PGF, Sin3ARNAi.UAS.WIZ

      (Swaminathan and Pile, 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Gcn5C137T/+ partially suppresses the wing phenotype induced by Scer\GAL4Ser.PGF>Sin3AdsRNA.Scer\UAS.WIZ.

      (Swaminathan and Pile, 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      FlyBase curator comment: the authors name this allele Gcn5[C137T] but the official symbol has been changed to reflect the correct amino acid replacement (C137Y).

      (Carre et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Gcn5C137T
      Gcn5C137Y
      Pcaf C137T
      (Swaminathan and Pile, 2010)
      PcafC137T
      (Swaminathan and Pile, 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)