FlyBase Allele Report: Dmel\GLaz[EP2383]

General Information

Symbol

Dmel\GLaz^EP2383

Species

D. melanogaster

Name

FlyBase ID

FBal0193459

Feature type

allele

Associated gene

Dmel\GLaz

Associated Insertion(s)

P{EP}GLaz^EP2383

Carried in Construct

Also Known As

EP2383

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}GLaz^EP2383

Cytology

Description

The insertion in P{EP}GLaz^EP2383 is 1.5kb upstream of GLaz.

(Walker et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:13,168,031..13,168,031 [-]

(Del Caño-Espinel et al., 2015, Walker, 2006, Walker et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal stress response, with Scer\GAL4^da.G32

(Walker et al., 2006)

long lived | heat sensitive, with Scer\GAL4^12.1

(Walker et al., 2006)

long lived | heat sensitive, with Scer\GAL4^109(2)80

(Walker et al., 2006)

long lived | heat sensitive, with Scer\GAL4^GMR.PF

(Walker et al., 2006)

long lived | heat sensitive, with Scer\GAL4^how-24B

(Walker et al., 2006)

long lived | heat sensitive, with Scer\GAL4^hs.PB

(Walker et al., 2006)

long lived | heat sensitive, with Scer\GAL4^Lk6-DJ634

(Walker et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

GLaz^EP2383 induction, under the control of Scer\GAL4^da.G32 results in greater resistance to hyperoxia.

GLaz^EP2383 induction, under the control of Scer\GAL4^da.G32 leads to an increase in mean lifespan at 29^oC of 18%.

Expression of GLaz^EP2383, under the control of Scer\GAL4^D42, Scer\GAL4^Act5C or Scer\GAL4^elav-C155 at 29^oC does not have any beneficial effect on lifespan, although expression under the control of Scer\GAL4^hs.PB gives a notable lifespan extension (21% increase over wild-type).

Expression of GLaz^EP2383 in the central nervous system and some muscles, under the control of Scer\GAL4^12.1 at 29^oC results in an 18% increase in lifespan.

Expression of GLaz^EP2383 in the central nervous system and some muscles, under the control of Scer\GAL4^109(2)80 at 29^oC results in an 29% increase in lifespan.

Expression of GLaz^EP2383 in the fat and some muscles, under the control of Scer\GAL4^Lk6-DJ634 at 29^oC results in an 17% increase in lifespan.

Expression of GLaz^EP2383 in the fat and some muscles, under the control of Scer\GAL4^how-24B at 29^oC results in an 10% increase in lifespan.

Expression of GLaz^EP2383 in the eye and salivary glands, under the control of Scer\GAL4^GMR.PF at 29^oC results in an 22% increase in lifespan.

(Walker et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EP(2)2383

(Walker et al., 2006)

GLaz^EP2383

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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