FB2024_03 , released June 25, 2024
Allele: Dmel\tinABD
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General Information
Symbol
Dmel\tinABD
Species
D. melanogaster
Name
FlyBase ID
FBal0197275
Feature type
allele
Associated gene
Dmel\tin
Associated Insertion(s)
Carried in Construct
P{tin-ABD}
Also Known As
tin-ABD
Key Links
Transgenic product class
genomic_DNA
(Zaffran et al., 2006)
wild_type
(Zaffran et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Zaffran et al., 2006)
wild_type
(Zaffran et al., 2006)
Mutagen
in vitro construct
(Zaffran et al., 2006)
Progenitor genotype
tinAB
(Zaffran et al., 2006)
Carried in construct
P{tin-ABD}
Cytology
Description

Sequences encoding the tin D (dorsal mesoderm) enhancer have been inserted downstream of the tinAB genomic fragment.

(Zaffran et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
tin
Encoded product / tool
tin
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tinEC40/tinABD mutant embryos show cardioblast (CB) patterning defects.

      (Schwarz et al., 2018)

      The myofibrils of the dorsal vessel are arranged almost exclusively in an anterior-posterior orientation in tinABD ; tin346/tinEC40 larvae, in contrast to wild-type larvae where they are arranged spirally. In the posterior heart region of the dorsal vessel the pattern of myofibrils is highly irregular in the mutant larvae, forming abnormal cross-shaped or 'knotted' patterns. The aorta appears thinner than normal in the mutant larvae, whereas the heart frequently has a wider diameter than normal.

      The heart tube is much thinner than normal in tinABD ; tin346/tinEC40 adults. The mutant myofibrils are arranged longitudinally and transverse spirally arranged myofibrils are almost completely absent.

      tinABD ; tin346/tin346 and tinABD ; tinABD tin346/tinEC40 adults show a dramatic increase in heart failure rate after pacing of the heart by external electrical stimulus compared to the heart failure rate of control adults. The recovery rate after heart failure is dramatically decreased in the mutant adults.

      tinABD ; tin346/tin346 and tinABD ; tinABD tin346/tinEC40 adults have a reduced lifespan compared to controls.

      (Zaffran et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      tinABD, tinEC40 has embryonic cardioblast phenotype, non-enhanceable by edlk06602

      (Schwarz et al., 2018)

      tinABD, tinEC40 has heart primordium phenotype, non-enhanceable by edlk06602

      (Schwarz et al., 2018)
      NOT suppressed by
      Statement
      Reference

      tinABD, tinEC40 has embryonic cardioblast phenotype, non-suppressible by edlk06602

      (Schwarz et al., 2018)

      tinABD, tinEC40 has heart primordium phenotype, non-suppressible by edlk06602

      (Schwarz et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The cardioblast patterning defects observed in tinEC40/tinABD mutant embryos are not modified by edlk06602.

      (Schwarz et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      tinABD partially rescues tin346

      (Zaffran et al., 2006)
      Comments

      tin346 embryos that are expressing tinABD show nearly normal expression of general cardioblast markers. The morphology of the posterior 'heart' region of the dorsal vessel is abnormal in these embryos; the cardioblast rows are uneven, some cardioblasts appear intercalated, and the shape of the cardioblasts is less regular than in control embryos.

      (Zaffran et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tinABD
      (Zhang et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)