FlyBase Allele Report: Dmel\edl[k06602]

(Schwarz et al., 2018, Bianchi-Frias et al., 2004, Vivekanand et al., 2004, Baker et al., 2001, Spradling et al., 1999, Roch et al., 1998, Beaton, 1997.3.4, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

denticle belt & embryonic abdominal segment 1

(Baker et al., 2001)

denticle belt & embryonic abdominal segment 2

(Baker et al., 2001)

denticle belt & embryonic abdominal segment 3

(Baker et al., 2001)

denticle belt & embryonic abdominal segment 4

(Baker et al., 2001)

embryonic cardioblast

(Schwarz et al., 2018)

embryonic cardioblast (with Df(2R)edl-S0520)

(Schwarz et al., 2018)

embryonic cardioblast (with Df(2R)Exel7157)

(Schwarz et al., 2018)

embryonic ostial cardioblast

(Schwarz et al., 2018)

embryonic ostial cardioblast (with Df(2R)Exel7157)

(Schwarz et al., 2018)

embryonic ventral epidermis & embryonic abdominal segment 1

(Baker et al., 2001)

embryonic ventral epidermis & embryonic abdominal segment 2

(Baker et al., 2001)

embryonic ventral epidermis & embryonic abdominal segment 3

(Baker et al., 2001)

embryonic ventral epidermis & embryonic abdominal segment 4

(Baker et al., 2001)

heart primordium

(Schwarz et al., 2018)

heart primordium (with Df(2R)edl-S0520)

(Schwarz et al., 2018)

heart primordium (with Df(2R)Exel7157)

(Schwarz et al., 2018)

presumptive embryonic/larval central nervous system

(Tootle et al., 2003)

Detailed Description

Statement

Reference

edl^k06602/Df(2R)edl-S0520, edl^k06602/Df(2R)Exel7157 and edl^k06602 mutant embryos show cardioblast (CB) patterning defects; edl^k06602 and edl^k06602/Df(2R)Exel7157 mutants show a decrease in the overall number of cardioblasts, due to a severe decrease in the number of ostial cardioblasts, as compared to controls.

(Schwarz et al., 2018)

Neuronal differentiation in the central nervous system is inhibited in homozygous embryos.

(Tootle et al., 2003)

Denticle belts are narrowed along the midline, in abdominal segments 1 to 4. This is reminiscent of phenotypes shown by rho and pnt mutant embryos.

(Baker et al., 2001)

Lethality occurs during third instar larval or pupal stages. Mutants do not show any visible disc abnormalities.

(Roch et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

edl^k06602 has decreased cell number | embryonic stage phenotype, enhanceable by aop¹/Df(2L)Exel6006

(Schwarz et al., 2018)

Suppressed by

Statement

Reference

edl^k06602 has decreased cell number | embryonic stage phenotype, suppressible by mid¹/mid¹

(Schwarz et al., 2018)

edl^k06602 has decreased cell number | embryonic stage phenotype, suppressible by pnt^Δ88

(Schwarz et al., 2018)

Enhancer of

Statement

Reference

edl^k06602 is an enhancer of decreased cell number | embryonic stage phenotype of aop¹/Df(2L)Exel6006

(Schwarz et al., 2018)

edl[+]/edl^k06602 is an enhancer of visible phenotype of aop^ACT.sev

(Vivekanand et al., 2004)

NOT Enhancer of

Statement

Reference

edl^k06602 is a non-enhancer of increased cell number | embryonic stage phenotype of pnt^Δ88

(Schwarz et al., 2018)

Suppressor of

Statement

Reference

edl[+]/edl^k06602 is a suppressor of visible phenotype of Ras85D^V12.sev

(Tootle et al., 2003)

NOT Suppressor of

Statement

Reference

edl^k06602 is a non-suppressor of increased cell number | embryonic stage phenotype of pnt^Δ88

(Schwarz et al., 2018)

Other

Statement

Reference

edl^k06602, hryⁱ²²/h[+] has partially lethal phenotype

(Bianchi-Frias et al., 2004)

edl^k06602, h[+]/hry²⁶ has partially lethal phenotype

(Bianchi-Frias et al., 2004)

edl^k06602, hry²⁶ has partially lethal phenotype

(Bianchi-Frias et al., 2004)

edl^k06602, hryⁱ²² has partially lethal phenotype

(Bianchi-Frias et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

edl^k06602 has embryonic ostial cardioblast phenotype, enhanceable by aop¹/Df(2L)Exel6006

(Schwarz et al., 2018)

edl^k06602 has heart primordium phenotype, enhanceable by aop¹/Df(2L)Exel6006

(Schwarz et al., 2018)

edl^k06602 has embryonic cardioblast phenotype, enhanceable by aop¹/Df(2L)Exel6006

(Schwarz et al., 2018)

Suppressed by

Statement

Reference

edl^k06602 has embryonic cardioblast phenotype, suppressible by pnt^Δ88

(Schwarz et al., 2018)

edl^k06602 has embryonic ostial cardioblast phenotype, suppressible by pnt^Δ88

(Schwarz et al., 2018)

edl^k06602 has heart primordium phenotype, suppressible by pnt^Δ88

(Schwarz et al., 2018)

edl^k06602 has embryonic ostial cardioblast phenotype, suppressible by mid¹/mid¹

(Schwarz et al., 2018)

edl^k06602 has heart primordium phenotype, suppressible by mid¹/mid¹

(Schwarz et al., 2018)

Enhancer of

Statement

Reference

edl^k06602 is an enhancer of heart primordium phenotype of aop¹

(Schwarz et al., 2018)

edl^k06602 is an enhancer of embryonic cardioblast phenotype of aop¹/Df(2L)Exel6006

(Schwarz et al., 2018)

edl^k06602 is an enhancer of embryonic ostial cardioblast phenotype of aop¹/Df(2L)Exel6006

(Schwarz et al., 2018)

edl[+]/edl^k06602 is an enhancer of eye phenotype of aop^ACT.sev

(Vivekanand et al., 2004)

NOT Enhancer of

Statement

Reference

edl^k06602 is a non-enhancer of embryonic cardioblast phenotype of tin^ABD, tin^EC40

(Schwarz et al., 2018)

edl^k06602 is a non-enhancer of heart primordium phenotype of tin^ABD, tin^EC40

(Schwarz et al., 2018)

edl^k06602 is a non-enhancer of embryonic ostial cardioblast | increased number phenotype of pnt^Δ88

(Schwarz et al., 2018)

edl^k06602 is a non-enhancer of embryonic cardioblast | increased number phenotype of pnt^Δ88

(Schwarz et al., 2018)

Suppressor of

Statement

Reference

edl[+]/edl^k06602 is a suppressor of eye phenotype of Ras85D^V12.sev

(Tootle et al., 2003)

edl[+]/edl^k06602 is a suppressor of ommatidium phenotype of Ras85D^V12.sev

(Tootle et al., 2003)

edl[+]/edl^k06602 is a suppressor of photoreceptor cell R7 | increased number phenotype of Ras85D^V12.sev

(Tootle et al., 2003)

NOT Suppressor of

Statement

Reference

edl^k06602 is a non-suppressor of embryonic cardioblast phenotype of tin^ABD, tin^EC40

(Schwarz et al., 2018)

edl^k06602 is a non-suppressor of heart primordium phenotype of tin^ABD, tin^EC40

(Schwarz et al., 2018)

edl^k06602 is a non-suppressor of embryonic ostial cardioblast | increased number phenotype of pnt^Δ88

(Schwarz et al., 2018)

edl^k06602 is a non-suppressor of embryonic cardioblast | increased number phenotype of pnt^Δ88

(Schwarz et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

edl^k06602, pnt^Δ88 double mutant embryos show an increase in the number of cardioblasts, which is similar to what is observed in pnt^Δ88 single mutants and unlike the decrease observed in edl^k06602 single mutants.

The decreased number of cardioblasts observed in aop¹/Df(2L)Exel6006 and edl^k06602 single mutant embryos is slightly more severe in the double mutants.

The cardioblast patterning defects observed in tin^EC40/tin^ABD mutant embryos are not modified by edl^k06602.

The decreased number of ostial cardioblasts observed in edl^k06602 mutant embryos is rescued by mid¹ homozygosity.

(Schwarz et al., 2018)

The rough eye phenotype caused by aop^ACT.sev is enhanced if the flies also carry edl^k06602/+.

(Vivekanand et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

edl^k12907

(BDGP Project Members, 1994-1999)