mae, l(2)k06602, modulator of the activity of Ets
Please see the JBrowse view of Dmel\edl for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\edl using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Expression of edl transcript is transient in the eye disc. Expression occurs in clusters of cells in two rows of the morphogenetic furrow. These cells correspond to the R8 cell and the R2/R5 cells when they have induction potential. Expression is also detected in underlying glial cells. Expression of edl in chordotonal organs precursons occurs in C1-C5 at the time they are induction competent.
JBrowse - Visual display of RNA-Seq signals
View Dmel\edl in JBrowse2-86
2-91.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Loss of edl function results in a reduced number of photoreceptor neurons and chordotonal organs.
Identification: In a yeast two hybrid system for proteins that interact with aop.
edl encodes a signalling intermediate that directly links the MAPK signaling pathway to its downstream transcription factor targets.
Area matching Drosophila EST AA441029.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
A negative regulator of photoreceptor neuronal development, acting downstream of Ras85D.
Source for merge of: edl mae
Source for merge of: edl anon-WO02077276.2 anon-WO02077276.3
Source for identity of mae CG15085 was sequence comparison ( date:010530 ).
Source for merge of edl anon-WO02077276.2 anon-WO02077276.3 was sequence comparison ( date:051113 ).
Source for identity of: mae l(2)k06602
Source for identity of: mae CG15085