D-ets-3, Ets
Ets domain transcription factor - regulation of cholinergic cell fate - acts combinatorially to control T1 neuron morphogenesis in the optic lobe, brain and CNS
Please see the JBrowse view of Dmel\Ets65A for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Triple stop-codon suppression (UGA, UAA, UGA) postulated (FlyBase analysis); supported by conservation of the extended ORF across Drosophila species (FBrf0202906).
Gene model reviewed during 6.02
0.8 (northern blot)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ets65A using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as dorsal/lateral sensory complexes
Ets65A transcripts are present at approximately equal levels throughout development. They are expressed throughout the embryo during germ band extension. During germ band retraction, expression becomes increasingly restricted to the ventral nerve cord. Expression is stronger in thoracic segments than in abdominal segments. Expression is reduced in the thoracic segments in the absence of the bithorax complex.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ets65A in JBrowse3-16
3-14.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release.
Ets65A has been cloned, sequenced and its RNA expression pattern characterised.
Source for merge of: Ets65A CG6882 CG13294
Annotations CG7018, CG6882 and CG13294 merged as CG7018 in release 3 of the genome annotation.
Source for identity of: Ets65A CG7018