FlyBase Allele Report: Dmel\Ero1L[GD3577]

General Information

Symbol

Dmel\Ero1L^GD3577

Species

D. melanogaster

Name

FlyBase ID

FBal0206983

Feature type

allele

Associated gene

Dmel\Ero1L

Associated Insertion(s)

Carried in Construct

P{GD3577}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD3577}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD3577

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | somatic clone, with Scer\GAL4^unspecified

(Wang et al., 2015)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Wang et al., 2015)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130, Scer\GAL80^Su(H).GBE

(Wang et al., 2015)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

adult gut, with Scer\GAL4^NP5130

(Wang et al., 2015)

adult gut, with Scer\GAL4^NP5130, Scer\GAL80^Su(H).GBE

(Wang et al., 2015)

adult gut | somatic clone, with Scer\GAL4^unspecified

(Wang et al., 2015)

wing vein

(Tien et al., 2008)

Detailed Description

Statement

Reference

Expression of Ero1L^GD3577 under the control of Scer\GAL4^esg-NP5130 or Scer\GAL4^esg-NP5130 combined with Scer\GAL80^Su(H).GBE (and using tub-Gal80[ts] to limit the time of expression) results in increased cell proliferation in the adult gut. Somatic MARCM clones expressing the RNAi under the Scer\GAL4^unspecified driver contain highly increased number of cells relative to control clones.

(Wang et al., 2015)

Reducing the levels of Ero1L through expression of Ero1L^GD3577 under the control of Scer\GAL4^nub.PK, results in a mild wing vein-thickening phenotype.

(Tien et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ero1L^GD3577, Scer\GAL4^NP5130 has increased occurrence of cell division | adult stage phenotype, suppressible by Xbp1^UAS.RB, Scer\GAL4^NP5130

(Wang et al., 2015)

Ero1L^GD3577, Scer\GAL4^NP5130 has increased occurrence of cell division | adult stage phenotype, suppressible by cnc^UAS.cSa, Scer\GAL4^NP5130

(Wang et al., 2015)

Ero1L^GD3577, Scer\GAL4^NP5130 has increased occurrence of cell division | adult stage phenotype, suppressible by PEK^GD5584, Scer\GAL4^NP5130

(Wang et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ero1L^GD3577, Scer\GAL4^NP5130 has intestinal stem cell | adult stage phenotype, suppressible by Xbp1^UAS.RB, Scer\GAL4^NP5130

(Wang et al., 2015)

Ero1L^GD3577, Scer\GAL4^NP5130 has intestinal stem cell | adult stage phenotype, suppressible by cnc^UAS.cSa, Scer\GAL4^NP5130

(Wang et al., 2015)

Ero1L^GD3577, Scer\GAL4^NP5130 has intestinal stem cell | adult stage phenotype, suppressible by PEK^GD5584, Scer\GAL4^NP5130

(Wang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The increased cell proliferation in the adult gut observed in flies expressing Ero1L^GD3577 under the control of Scer\GAL4^esg-NP5130 (and using tub-Gal80[ts] to limit the time of expression) is suppressed by co-expression of any of the following: Xbp1^Scer\UAS.RB, cnc^Scer\UAS.cSa or PEK^GD5584.

(Wang et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v51169

w¹¹¹⁸; P{GD3577}v51169

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ero1L^GD3577

Ero1L^RNAi

(Wang et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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