FB2024_03 , released June 25, 2024
Allele: Dmel\Stat92EGD4492
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General Information
Symbol
Dmel\Stat92EGD4492
Species
D. melanogaster
Name
FlyBase ID
FBal0208645
Feature type
allele
Associated gene
Dmel\Stat92E
Associated Insertion(s)
Carried in Construct
P{GD4492}
Also Known As
UAS-stat92eRNAi, stat92E RNAi, UAS-Stat92E-RNAi, UAS-statRNAi, UAS-Stat92E RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD4492}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD4492
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal cell number | larval stage | conditional, with Scer\GAL4dome-PG14

      (Rodrigues et al., 2021)

      abnormal cell number | larval stage | conditional, with Scer\GAL4Ubx-M3

      (Rodrigues et al., 2021)

      abnormal immune response, with Scer\GAL40421-G4

      (Rodrigues et al., 2021)

      abnormal immune response | larval stage, with Scer\GAL4dome-PG14

      (Rodrigues et al., 2021)

      abnormal immune response | larval stage, with Scer\GAL4Tep4.PK

      (Rodrigues et al., 2021)

      abnormal immune response | larval stage, with Scer\GAL4Ubx-M3

      (Rodrigues et al., 2021)

      abnormal stress response | RU486 conditional, with Scer\GAL4Act5C.Switch.PR

      (Kallio et al., 2010)

      decreased cell number | male | third instar larval stage, with Scer\GAL4C587

      (La Marca et al., 2019)

      decreased size | adult stage, with Scer\GAL4ey.PU

      (Harsh et al., 2020)

      increased mortality during development, with Scer\GAL40421-G4

      (Rodrigues et al., 2021)

      increased mortality during development, with Scer\GAL4Ubx-M3

      (Rodrigues et al., 2021)

      increased mortality during development | conditional, with Scer\GAL4dome-PG14

      (Rodrigues et al., 2021)

      increased mortality during development | conditional, with Scer\GAL4Tep4.PK

      (Rodrigues et al., 2021)

      partially lethal - majority die, with Scer\GAL4pnr-MD237

      (Mummery-Widmer et al., 2009)

      some die during pupal stage, with Scer\GAL4pnr-MD237

      (Mummery-Widmer et al., 2009)

      viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu

      (Neely et al., 2010)

      viable, with Scer\GAL4tin.CΔ4

      (Neely et al., 2010)

      visible, with Scer\GAL4pnr-MD237

      (Mummery-Widmer et al., 2009)

      visible | adult stage, with Scer\GAL4ey.PU

      (Harsh et al., 2020)
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Stat92EGD4492 under the control of Scer\GAL4ey.PU leads to a decrease in the size of eye.

      (Harsh et al., 2020)

      Expressing Stat92EGD4492 under the control of Scer\GAL4C587 leads to early germline cell loss in L3 male gonads.

      (La Marca et al., 2019)

      The expression of Stat92EGD4492 under the control of Scer\GAL4ey.PH does not have an obvious effect on the adult eye size compared to controls.

      (Clemente-Ruiz et al., 2016)

      Flies expressing Stat92EGD4492 under the control of Scer\GAL4Act5C.Switch.PR (induced by Mifepristone) show decreased survival in food contaminated with S. marcescens (an entomopathogenic bacterium) than controls.

      (Kallio et al., 2010)

      Adults expressing Stat92EGD4492 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or late pupal lethality.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

      Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 0% or 30-40% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

      Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 0% or 70-80% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT suppressed by
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4ey.PU, Stat92EGD4492 has eye phenotype, enhanceable by ZIKV\NS4AUAS.Tag:FLAG/Scer\GAL4ey.PU

      (Harsh et al., 2020)
      NOT suppressed by
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Stat92EGD4492 under the control of Scer\GAL4arm.PU partially rescues the reduced fecundity of Ptp61FΔ females.

      (Buszard et al., 2013)

      The melanotic tumour phenotype see in animals carrying gcmDN.Scer\UAS.T:en-Rep, Scer\GAL4srp.D.cCa and Scer\GAL80ts.αTub84B which have been raised at 18[o]C and then shifted to 29[o]C during the first larval instar stage is completely suppressed if they are also co-expressing Stat92EGD4492.

      (Jacques et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Stat92EGD4492
      (Bailetti et al., 2019)
      Stat92ERNAi
      (Bhaskar et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (30)