FlyBase Allele Report: Dmel\Traf6[GD7146]

General Information

Symbol

Dmel\Traf6^GD7146

Species

D. melanogaster

Name

FlyBase ID

FBal0208835

Feature type

allele

Associated gene

Dmel\Traf6

Associated Insertion(s)

Carried in Construct

P{GD7146}

Also Known As

UAS-dTRAF2^RNAi, UAS-TRAF2-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD7146}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD7146

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates human immunodeficiency virus infectious disease

modeled by HIV-1\Vpu^UAS.cLa

(Marchal et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

intestinal stem cell | chemical conditional, with Scer\GAL4^NP0001

(Tang et al., 2013)

intestinal stem cell | chemical conditional, with Scer\GAL4^NP5130

(Tang et al., 2013)

Detailed Description

Statement

Reference

Expressing Traf6^GD7146 under the control of Scer\GAL4^C587 (together with Dicer-2, for a more efficient RNAi) does not induce any major L3 spermatogenesis defects.

(La Marca et al., 2019)

Adults expressing Traf6^GD7146 under the control of Scer\GAL4^NP0001 do not exhibit significant mortality to Ecc15 enteric infection, as compared to controls.

(Lee et al., 2018)

Expression of Traf6^GD7146 under the control of either Scer\GAL4^esg-NP5130 or Scer\GAL4^{Myo31DF-NP0001} results in impaired intestinal stem cell proliferation in response to paraquat.

(Tang et al., 2013)

Adults expressing Traf6^GD7146 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in viable flies or early pupal lethality.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7146

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Traf6^GD7146/Scer\GAL4^C587 is a suppressor | partially of abnormal size | recessive | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

Traf6^GD7146/Scer\GAL4^ptc-559.1 is a suppressor of abnormal size | dominant | female | larval stage phenotype of HUWE1^B

(Yanku et al., 2018)

Traf6^GD7146/Scer\GAL4^rn-GAL4-5 is a suppressor | partially of increased cell death phenotype of Scer\GAL4^rn-GAL4-5, egr^UAS.cMa

(Andersen et al., 2015)

Traf6^GD7146, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Atg9^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Tang et al., 2013)

Traf6^GD7146, Scer\GAL4^GMR.PU is a suppressor of increased cell death | third instar larval stage phenotype of Atg9^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Tang et al., 2013)

Traf6^GD7146/Scer\GAL4^Act5C.PU is a suppressor of chemical resistant | dominant phenotype of puc^B48

(Tang et al., 2013)

Traf6^GD7146, Scer\GAL4^dpp.blk1 is a suppressor | partially of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Other

Statement

Reference

Scer\GAL4^Act5C.PU, Traf6^GD7146, puc^B48 has chemical sensitive phenotype

(Tang et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Traf6^GD7146/Scer\GAL4^C587 is a suppressor | partially of gonad | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

Traf6^GD7146/Scer\GAL4^ptc-559.1 is a suppressor of embryonic/larval salivary gland | female | larval stage phenotype of HUWE1^B

(Yanku et al., 2018)

Traf6^GD7146/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, egr^UAS.cMa

(Andersen et al., 2015)

Traf6^GD7146, Scer\GAL4^dpp.blk1 is a suppressor | partially of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Traf6^GD7146 under the control of Scer\GAL4^Act5C.PU suppresses the resistance to paraquat seen in puc^B48/+ mutant flies. Mortality rates are increased compared to controls.

Expression of Traf6^GD7146 suppresses the rough eye phenotype and third instar larval eye disc cell death seen when Atg9^{Scer\UAS.T:Zzzz\FLAG} is expressed under the control of Scer\GAL4^GMR.PU.

(Tang et al., 2013)

Xenogenetic Interactions

Statement

Reference

Co-expression of Traf6^GD7146 partially suppresses the wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1.

(Marchal et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v16125

w¹¹¹⁸; P{GD7146}v16125

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7146

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Traf2^GD7146

Traf6^GD7146

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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