FlyBase Allele Report: Dmel\baz[GD1384]

General Information

Symbol

Dmel\baz^GD1384

Species

D. melanogaster

Name

FlyBase ID

FBal0209111

Feature type

allele

Associated gene

Dmel\baz

Associated Insertion(s)

Carried in Construct

P{GD1384}

Also Known As

UAS-baz RNAi, baz^RNAi, baz RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1384}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1384

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of developmental disorder of mental health

CEA

(Stessman et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates hematologic cancer

modeled by hop^Tum

(Bina et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^C57

(Ramachandran et al., 2009)

lethal, with Scer\GAL4^Act5C.PU

(Dietzl et al., 2007)

lethal, with Scer\GAL4^αTub84B.PL

(Aranjuez et al., 2012)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of baz^GD1384 under the control of Scer\GAL4^ppk.PG does not interfere with the dendritic pruning in class IV dendritic arborizing neuron at the pupal stage.

(Herzmann et al., 2017)

Expression of baz^GD1384 under the control of either Scer\GAL4^slbo.2.6 or Scer\GAL4^c306 results in incomplete border cell migration in some stage 10 egg chambers.

Expression of baz^GD1384 under the control of Scer\GAL4^T155 results in a disrupted follicle cell epithelium in stage 9 and 10 egg chambers: regions of the epithelium are thin or multilayered and follicle cells fail to retract over the oocyte in some cases.

(Aranjuez et al., 2012)

Adults expressing baz^GD1384 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in loss of bristles on the notum in 50-60% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in duplication of bristle hairs on the notum in 0-10% or 10-20% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

Expression of baz^GD1384 under the control of Scer\GAL4^C57 in the muscles results in a reduction of postsynaptic F-actin at the larval neuromuscular junction. In addition, synaptic boutons are significantly reduced in number and show a significant increase in average volume compared to wild type.

(Ramachandran et al., 2009)

Expression of baz^GD1384 under the control of Scer\GAL4^c306 results in mild border follicle cell detachment defects as well as border cell migration defects.

(McDonald et al., 2008)

Expression of baz^GD1384 under the control of Scer\GAL4^pnr-MD237, results in missing macrochaetae, although this phenotype is mild.

(Dietzl et al., 2007)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1384

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^dome-PG5/baz^GD1384 is a suppressor of melanotic mass phenotype phenotype of hop^Tum

(Bina et al., 2010)

Scer\GAL4^insc-Mz1407/baz^GD1384 is a suppressor of abnormal neuroanatomy phenotype of l(2)gl¹/l(2)gl⁴

(Wirtz-Peitz et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, baz^GD1384 has macrochaeta phenotype, enhanceable by Dcr-2^UAS.cDa, Scer\GAL4^pnr-MD237

(Dietzl et al., 2007)

Suppressor of

Statement

Reference

Scer\GAL4^dome-PG5/baz^GD1384 is a suppressor of melanotic mass phenotype of hop^Tum

(Bina et al., 2010)

Scer\GAL4^insc-Mz1407/baz^GD1384 is a suppressor of larval neuroblast phenotype of l(2)gl¹/l(2)gl⁴

(Wirtz-Peitz et al., 2008)

Scer\GAL4^insc-Mz1407/baz^GD1384 is a suppressor of embryonic/larval brain | larval stage phenotype of l(2)gl¹/l(2)gl⁴

(Wirtz-Peitz et al., 2008)

Other

Statement

Reference

Dcr-2^UAS.cDa, Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH, baz^GD1384 has eye phenotype

(Dietzl et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The overproliferation of larval brain neuroblasts seen in l(2)gl¹/l(2)gl⁴ animals is completely suppressed by expression of baz^GD1384 under the control of Scer\GAL4¹⁴⁰⁷.

(Wirtz-Peitz et al., 2008)

While expression of baz^GD1384 alone, under the control of Scer\GAL4^ey.PH and Scer\GAL4^GMR.PF, does not lead to a significant eye phenotype, coexpression of Dcr-2^Scer\UAS.cDa with this transgene results in flies that have rough or necrotic eyes.

Coexpression of Dcr-2^Scer\UAS.cDa enhances the missing macrochaetae phenotype of Scer\GAL4^pnr-MD237>baz^GD1384 flies.

(Dietzl et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v2914

w¹¹¹⁸; P{GD1384}v2914

v2915

w¹¹¹⁸; P{GD1384}v2915

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1384

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

baz^GD1384

baz^RNAi

(Besson et al., 2015, Wirtz-Peitz et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (24)

Report Sections

Open Close