FlyBase Allele Report: Dmel\mor[GD1257]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\mor^GD1257

General Information

Symbol

Dmel\mor^GD1257

Species

D. melanogaster

Name

FlyBase ID

FBal0210097

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Transgenic product class

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of opportunistic bacterial infectious disease

CEA

(Bonnay et al., 2014)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response, with Scer\GAL4^c564

(Bonnay et al., 2014)

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

abnormal neuroanatomy | larval stage, with Scer\GAL4^wor.PA

(Eroglu et al., 2014)

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

lethal, with Scer\GAL4^Act5C.PU

(Dietzl et al., 2007)

lethal, with Scer\GAL4^en.PU

(Dietz et al., 2015)

lethal, with Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

(Dietzl et al., 2007)

lethal, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

lethal, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

lethal, with Scer\GAL4^pnr-MD237

(Dietzl et al., 2007)

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

partially lethal, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

partially lethal - majority die, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

visible | heat sensitive, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

eye, with Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

(Dietzl et al., 2007)

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

posterior crossvein, with Scer\GAL4^en.PU

(Dietz et al., 2015)

type II neuroblast | increased number, with Scer\GAL4^wor.PA

(Eroglu et al., 2014)

wing, with Scer\GAL4^Bx-MS1096

(Dietzl et al., 2007)

wing blade, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing blade, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

wing hair | ectopic | heat sensitive, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

wing margin | heat sensitive, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

wing sensillum | ectopic | heat sensitive, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

wing vein | heat sensitive, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

Detailed Description

Statement

Reference

Expression of mor^GD1257 is pupal lethal at 25[o]C when driven by Scer\GAL4^Act5C.PI, Scer\GAL4^nub.PK (leads to severe wing blistering at 18[o]C), Scer\GAL4^en.PU (leads to blisters and ectopic venation at the posterior crossvein at 18[o]C) or Scer\GAL4^ey.PH (with escapers showing small deformed eyes, at 18[o]C the flies display moderate rough eye phenotype). No overt adult phenotype is observed with the Scer\GAL4^GMR.PF driver.

(Dietz et al., 2015)

Flies expressing Scer\GAL4^c564>mor^GD1257 show a significant decrease in survival following Enterobacter cloacae (E. cloacae) or Erwinia carotovora Ecc15 infections when compared with control flies.

(Bonnay et al., 2014)

Larval brains expressing mor^GD1257 under the control of Scer\GAL4^wor.PA contain additional type II NB-like cells. Transplantation of this tissue into the abdomens of adult wild type hosts results in tumor formation.

(Eroglu et al., 2014)

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in an increase in the number of neuroblasts in the larval brain compared to controls.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in longer neuroblast lineages (more daughter cells per neuroblast) in the larval brain compared to controls.

(Neumüller et al., 2011)

Adults expressing mor^GD1257 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing mor^GD1257 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in early pupal lethality.

(Schnorrer et al., 2010)

Expression of mor^GD1257 in the wing under the control of Scer\GAL4^salm-459.2 at both 17[o]C and 25[o]C results in the loss of wing veins and wing margin, a reduction in wing size, and ectopic wing hair and sensory organs. The defects are more severe at 25[o]C.

(Terriente-Félix and de Celis, 2009)

Expression of mor^GD1257 under the control of Scer\GAL4^Bx-MS1096 results in curly and crinkled wings.

Expression of mor^GD1257 under the control of Scer\GAL4^ey.PH and Scer\GAL4^GMR.PF results in eyes that are small and rough in appearance.

(Dietzl et al., 2007)

External Data

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1257

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH, mor^GD1257 has lethal phenotype, enhanceable by Dcr-2^UAS.cDa, Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

(Dietzl et al., 2007)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

v6969

w¹¹¹⁸; P{GD1257}v6969

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 2 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1257

Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells

1257

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mor^GD1257

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections