FlyBase Allele Report: Dmel\sl[GD1535]

General Information

Symbol

Dmel\sl^GD1535

Species

D. melanogaster

Name

FlyBase ID

FBal0210605

Feature type

allele

Associated gene

Dmel\sl

Associated Insertion(s)

Carried in Construct

P{GD1535}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1535}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1535

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^Act5C.PU

(Dietzl et al., 2007)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^Bx-MS1096

(Friedman et al., 2011)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

(Dietzl et al., 2007)

wing, with Scer\GAL4^Bx-MS1096

(Friedman et al., 2011)

Detailed Description

Statement

Reference

Expression of sl^GD1535 driven by Scer\GAL4^phm.PO does not lead to developmental delay/arrest at the larval stage.

(Yamanaka et al., 2015)

Expression of sl^GD1535 under the control of Scer\GAL4^Bx-MS1096 results in ectopic wing veins.

(Friedman et al., 2011)

Adults expressing sl^GD1535 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression of sl^GD1535 under the control of Scer\GAL4^ey.PH and Scer\GAL4^GMR.PF results in a mild rough eye phenotype.

(Dietzl et al., 2007)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1535

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH, sl^GD1535 has eye phenotype, enhanceable by Dcr-2^UAS.cDa, Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

(Dietzl et al., 2007)

Other

Statement

Reference

Dcr-2^UAS.cDa, Scer\GAL4^pnr-MD237, sl^GD1535 has macrochaeta phenotype

(Dietzl et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of Dcr-2^Scer\UAS.cDa with sl^GD1535, under the control of Scer\GAL4^ey.PH and Scer\GAL4^GMR.PF, results in a slight enhancement of the mild sl^GD1535 rough eye phenotype.

Coexpression of Dcr-2^Scer\UAS.cDa with sl^GD1535, under the control of Scer\GAL4^pnr-MD237, leads to a mild missing macrochaetae phenotype that is not seen when sl^GD1535 is expressed alone.

(Dietzl et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v7173