FB2024_03 , released June 25, 2024
Allele: Dmel\PGRP-LCd07454
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General Information
Symbol
Dmel\PGRP-LCd07454
Species
D. melanogaster
Name
FlyBase ID
FBal0212185
Feature type
allele
Associated gene
Dmel\PGRP-LC
Associated Insertion(s)
P{XP}PGRP-LCd07454
Carried in Construct
Also Known As
PGRP-LC7454
Key Links
Genomic Maps

Allele class

loss of function allele

wild-type allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Gottar et al., 2002)

wild-type allele

(Gottar et al., 2002)
Mutagen
P-element activity
(Gene Disruption Project members and Exelixis, 2005, Gottar et al., 2002)
Progenitor genotype
Associated Insertion(s)
P{XP}PGRP-LCd07454
Cytology
Description

P{XP} element is inserted at nucleotide 72 in the first non-translated exon of PGRP-LC.

(Gottar et al., 2002)
Allele components
Component
Use(s)
Inserted element
P{XP}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PGRP-LCd07454 mutant adult flies exhibit increased susceptibility to Coxiella burnetii: their post-infection survival rate is significantly reduced compared to wild-type controls.

      (Bastos et al., 2017)

      Mutant animals have a reduced resistance to B.subtilis infection.

      (Takehana et al., 2004)

      PGRP-LC7454 and PGRP-LC7454/Df(3L)29A6 flies show a marked susceptibility to infection by Gram-negative bacteria (Agrobacterium tumefaciens, P.carotovorum.carotovorum and E.cloacae) compared to wild type, but have almost wild-type resistance to infection by Gram-positive bacteria (E.faecalis) or fungi (B.bassiana).

      (Gottar et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      PGRP-LCd07454 has abnormal immune response phenotype, enhanceable by PGRP-LE112

      (Takehana et al., 2004)
      Enhancer of
      Statement
      Reference

      PGRP-LCd07454 is an enhancer of abnormal immune response phenotype of PGRP-LE112

      (Takehana et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Unlike single mutants, PGRP-LC7454/PGRP-LE112 double mutant animals exhibit a reduced resistance to E.coli and B.megaterium infection, but not E.faecalis and M.luteus infection.

      (Takehana et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      PGRP-LCd07454 is rescued by PGRP-LCd07454/Scer\GAL4hs.PB

      (Gottar et al., 2002)
      Rescues

      PGRP-LCd07454/Scer\GAL4hs.PB rescues PGRP-LCd07454

      (Gottar et al., 2002)
      Comments

      Overexpression of PGRP-LC (by driving expression from the Scer\UAS sequences present in the P{XP}PGRP-LC7454 insertion using Scer\GAL4hs.PB) rescues the susceptibility of PGRP-LC7454 flies to infection by E.cloacae.

      (Gottar et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{XP} element can revert the susceptibility of PGRP-LC7454 flies to E.cloacae infection.

      (Gottar et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PGRP-LC7454
      (Bastos et al., 2017, Tsuzuki et al., 2012, Ferrandon, 2007.11.30)
      PGRP-LCd07454
      (Ferrandon, 2007.11.30)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0182394
      • FBal0135884
      References (6)